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Pathology > GYN > Flashcards

GYN Flashcards

1
Q

Which syndrome is Peutz Jeghers associated with in the gyn?

A

Adenoma Malignum

Ovarian Sex cord tumor with annular tubules

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2
Q

Peutz-Jeghers is due to Mutation in what gene? Chromosome?

A

STK11/LKB1

Chromosome 19p

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3
Q

In lynch syndrome:

_______% lifetime risk of endometrial cancer; often in the _________

_______% risk of ovarian cancer; often _______

A

___50_% lifetime risk of endometrial cancer; often in the lower uterine segment

___10____% risk of ovarian cancer; often clear cell type

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4
Q

What genes are associated with hereditary breast/ovary cancer (HBOC)?

A

BRCA1 and 2

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5
Q

What is the precursor lesion seen in hereditary breast/ovary cancer (HBOC) in the Fallopian tube?

A

Serous tubal intraepithelial carcinoma

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6
Q

What chromosome is BRACA 1?

A

17q21

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7
Q

What chromosome is BRACA 2?

A

13q12-13

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8
Q

High risk HPV

A

16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, 82

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9
Q

Infections that result in benign processes usually have _________ viral DNA

A

Episomal

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10
Q

How is mutated BRCA expressed?

A

AD with high penetrance

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11
Q

E6 gene product act through inhibition of what tumor suppressor gene?

A

p53

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12
Q

E7 gene product act through inhibition of what tumor suppressor gene? Which causes?

A

Retinoblastoma Over expression of p16

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13
Q

Is lichen sclerosis a precancerous lesion?

A

No

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14
Q

Does lichen sclerosis have a greater risk of carcinoma?

A

Yes; 1-4%

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15
Q

Lichen simplex chronicus: histologic

A

Hyperkeratosis with acanthosis

Collagenization of the superficial dermis with underlying chronic inflammatory infiltrate

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16
Q

DES is associated with alteration of what gene?

A

P63

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17
Q

Serous carcinoma IHC

A

p53 and p16 diffusekt positive

p53 maybe completely negative

18
Q

Ovarian tumors with esteogenic effect

A

Granulosa cell tumor
Thecomas
Stromal luteoma

19
Q

Ovarian tumors with androgenic effect

A

Sertoli leydig
Leydig/Hilus cell tumor
Steroid cell tumor

20
Q

Ovarian tumor of the young <30

A

Sertoli leydig (retifrom variant seen ~15)
Juvenile granulosa
Sclerosing stromal tumor
Sex cord stromal tumor with annular tubules

21
Q

Ovarian tumors of perimenopausal age

A

Fibromas

22
Q

Ovarian tumors of post menopausal age

A

Adult granulosa
Thecomas
Leydig
Stromal luteoma

23
Q

What is the maximum number of slides a tech can screen? What’s the calculation?

A

100 in 24 hours (in no less than 8 hours)

Number of hours * 100 /8

24
Q

Whats the gene product of HPV that’s used in vaccines?

A

L1

25
Q

Give the risk of developing HSIL or worse in the following scenarios…

Neg Pap and Neg HPV
Neg Pap and Positive Pooled HPV
Neg pap and Positive for HPV 16
ASCUS and Positive HPV

A

Neg Pap and Neg HPV : <2%
Neg Pap and Positive Pooled HPV: 3-5%
Neg pap and Positive for HPV 16: 20%
ASCUS and Positive HPV : 25-30%

26
Q

Give the Regression %, Progression to HSIL % and Progression to Cancer % in following
ASCUS :
LSIL:
HSIL :

A

Regression HSIL Cancer

ASCUS : 68% 7% 0.25%
LSIL: 47% 21% 0.15%
HSIL : 35% —- 1.4%

27
Q

Given the associated hormonal status

0/10/90
0/90/10
20/80/0
100/0/0

A

0/10/90 : Estrogen effect
0/90/10 : Progesterone effect, New borns
20/80/0 : Androgen effect
100/0/0 : Atrophy, no estrogen

Parabasal/intermediate/sperficial

28
Q

What defines the Pap as “ High risk” ?

A

Onset of sexual activity before 16
Multiple sexual partners (>5 in a lifetime)
Hx of STD, including HIV
Fewer then 3 neg paps in the last 7 years
Daughter of a women given DES
Abnormal pap in the last 3 years in a women of childbearing age

29
Q

Whats the minimum number of cells in liquid Paps?

A

5000 cells

30
Q

Whats the next step in management?

Unsat pap
If Unsat and HPV HR+
NILM but no EC/TZ

A

Unsat pap : Repeat in 2-4 months
Unsat and HPV HR+ : colpo
NILM but no EC/TZ : Routine screening

31
Q

ASC-H will show a cin2 or worse on biopsy in what percentage of women?

A

40%

32
Q

Gardasil covers what HPV types?

A

16,18,6,11

33
Q

When should women start screening?

A

21

34
Q

omen between the ages of 21 and 29 should have a Pap test every____ years

A

Women between the ages of 21 and 29 should have a Pap test every 3 years

35
Q

For women 30-65 how often should they get pap test? What about HPV?

A

Women between the ages of 30 and 65 should have both a Pap test and an HPV test every 5 years. This is the preferred approach, but it is also OK to have a Pap test alone every 3 years.

36
Q

When can women stop having paps?

A

At age 65, or hysterectomy for benign reasons

37
Q

Can you stop if you get the Gardasil?

A

No, continue per recommendation of age group

38
Q

How many cells are need per HPF for adequecy?

Thin prep
Surepath

A

Thin prep 3-4

Surepath 7-8

39
Q

Match The following: 13mm, 20 mm, Vacuum, Centrifuge

Thin Prep
Surepath

A

Thin Prep 20 mm Vacuum filtration

Surepath 13mm Centrifuged

40
Q

What type of virus is HPV

A

Nonenveloped DS DNA (Others in this group is the adenoviridae and the polyomaviridae)

Pathology (16 decks)

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