Malignant Hematopathology - Krafts

Question 1

Define Leukemia (cell type, starts where? spreads where? infected cell lines? Types of disease)

Answer 1

Malignancy of hematopoietic cells
Starts in bone marrow, can spread to blood, nodes
Myeloid or lymphoid
Acute or chronic

Question 2

Define Lymphoma (cell type, starts where? spreads where? infected cell line? Types of disease)

Answer 2

Malignancy of hematopoietic cells
Starts in lymph nodes, can spread to blood, marrow
Lymphoid only
Hodgkin or non-Hodgkin

Question 3

How is a malignant diagnosis made?

Answer 3

Clinical setting
Morphology
Immunophenotyping
Molecular Studies
Cytogenetics

Question 4

What type of needle is used in a bone marrow biopsy?

Answer 4

Jamshidi Needle

Question 5

What kinds of cells make up acute leukemias?

Answer 5

Young Cells

Question 6

What kinds of cells make up chronic leukemias?

Answer 6

Mature Cells

Question 7

What kinds of cells make up Hodgkin lymphoma?

Answer 7

Reed-Sternberg Cells

Question 8

What kind of cells make up myeloma?

Answer 8

Plasma Cells

Question 9

What type of stain is used to see monocytes (makes them orange)?

Answer 9

Cytochemical stain with non-specific esterase

Question 10

Philadelphia Chromosome Translocation 9-22 is associated with what disease?

Answer 10

Chronic Myeloid Leukemia