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IHO Week 3 > ALL - Krafts > Flashcards

ALL - Krafts Flashcards

1
Q

Define Acute Lymphoblastic Leukemia

A

Malignant proliferation of lymphoid blasts in the blood and bone marrow

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2
Q

What are the characteristics of ALL?

A

Classified by immunophenotype: B vs. T-cells
More common in children
Good prognosis

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3
Q

Which type of ALL has a worse prognosis?

A

T-lymphoblastic leukemia

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4
Q

What markers do you look for in T-lymphoblastic Leukemia?

A

TdT

T-Cell Antigens for CD3,4,5,7,8

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5
Q

What markers do you look for in B-lymphoblastic Leukemia?

A

TdT

B-cell Antigens for CD19,20,21

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6
Q

T-Lymphoblastic Leukemia/Lymphoma Characteristics

A

Teenage male with mediastinal mass (Thymus)
HIGH WBC count
Poor Prognosis

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7
Q

B-Lymphoblastic Leukemia/Lymphoma Characteristics

A

TdT +

MOST common in Children

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8
Q

ALL Prognosis

A

T-Lymphoblastic is worse = make sure to Immunophenotype!!
Age 1-10 has Good Prognosis
Reasonable WBC count (

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9
Q

ALL Treatment

A

Chemotherapy
Possibly Bone Marrow Transplant
Curative without Bone Marrow Transplant

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IHO Week 3 (14 decks)

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