Antineoplastics II: Drugs that Prevent DNA Synthesis - Fitz Flashcards
1
Q
Define Antimetabolites
A
Analogues of folate, pyrimidine or purine that interfere with DNA synthesis
2
Q
What is the common mechanism for development of resistance in antimetabolites?
A
Changes in Target Enzymes
3
Q
What type of cell cycle agents are antimetabolites?
A
Cell Cycle Specific S-Phase
4
Q
What is Tumor Lysis Syndrome?
A
Development of electrolyte and metabolic disturbances that can produce life-threatening complications (hyperuricemia)
5
Q
Why is Allopurinol frequently used during chemotherapy of hematologic cancers?
A
Allopurinol is a xanthine oxidase inhibitor used to prevent hyperuricemia due to tumor lysis syndrome
6
Q
PRPP + hypoxanthine =
A
IMP
7
Q
PRPP + guanine =
A
GMP
