Antineoplastics III: Drugs that Disrupt DNA Flashcards
1
Q
What drug is hemorrhagic cystitis associated with?
A
Cyclophosphamide
2
Q
What class of drugs is cardiomyopathy associated with?
A
Anthracycline Antibiotics
3
Q
What are the cytotoxic drug side effects?
A
Bone marrow suppression
Gastritis
Alopecia
4
Q
What type of cell cycle agents are drugs that damage or disrupt DNA?
A
Cell Cycle Non-Specific
5
Q
When does primary toxicity occur in the cell cycle for drugs that damage or disrupt DNA?
A
Late G1 and S Phase
6
Q
What is the mechanism of action for alkylating agents?
A
Activation to an electrophile –> N7 Guanine Nucleophilic Attack –> Damage DNA
