Malignant hematopathology 12/19

Question 1

Leukemia

Answer 1

Infiltration of the BM by malignant cells of the blood

originates from cells already in BM

Question 2

Where do you get a BM sample from

Answer 2

From the axial skeleton like the iliac crest

Question 3

Lymphocytic markers

Answer 3

Question 4

Causes of neutrophilic leukocytosis

Answer 4

bacterial infx, sterile inflammation caused by tissue necrosis

Question 5

causes of eosinophilic leukocytosis

Answer 5

Allergies, parasitic infxn, hodgkin disease and some nonHL, collagen vascular disorders and some vasculitides, transient atheroembolic disease, drug reactions

Question 6

causes of basophilic leukocytosis

Answer 6

rare, CML (chronic myelogenous leukemia)

Question 7

causes of monocytosis

Answer 7

chronic infxn, bacterial endocarditis, rikettsiosis and malaria, IBD and collagen vascular disease

Question 8

in a reactive lymphoid follicle with germinal center, you’ll see

Answer 8

tingible body MQ and mantle zone

Question 9

Lymphoma

Answer 9

proliferation arising as discrete tissue masses, usually in LN

Hodgkin and NHL

Question 10

Acute vs. chronic leukemia

Answer 10

Acute: if untreated, will kill a pt quickly because it’s very aggressive and made up of immature primitive cells

Chronic: progresses slowly over many years, then one day will transform into acute and pt will die quickly

Question 11

Prognosis of acute vs. chronic leukemia

Answer 11

acute is more treatable than chronic because cells are dividing quickly

Acute affect more younger people while chronic affect the elder

Question 12

Pathologic finding in AML

Answer 12

Auer rods can be seen in blasts

Question 13

revised FAB classification of acute myelogenous leukemia

Answer 13

Question 14

multiple myeloma

Answer 14

malignant neoplasm of plasma cells

Question 15

WHO classification categories for hodgkin and NHL

Answer 15

precursor B-cell neoplasms (immature)

peripheral B-cell neoplasm (mature)

precursor T-cell neoplasm (immature)

Peripheral T-cell and NK neoplasm (mature)

Hodgkin lymphoma (neoplasm of Reed Sternberg cells)

Question 16

marginal zone lymphoma

Answer 16

special type of peripheral B cell NHL, also called MALToma:

associated with ongoing autoimmune process

stomach with H pylori

low grade and can be cured surgically

Question 17

Hodgkin lymphoma

Answer 17

localized to a single axial group of nodes

orderly spread by contiguity

mesenteric nodes and Waldeyer ring (pharyngeal nodes) rarely involved

uncommon extranodal involvement

Question 18

NHL

Answer 18

involvement of multiple peripheral nodes

noncontiguous spread

Waldeyer ring and mesenteric nodes involved

Common extranodal involvement

Question 19

Useful image

Answer 19