Malignant hematopathology 12/19 Flashcards
Leukemia
Infiltration of the BM by malignant cells of the blood
originates from cells already in BM
Where do you get a BM sample from
From the axial skeleton like the iliac crest
Lymphocytic markers
Causes of neutrophilic leukocytosis
bacterial infx, sterile inflammation caused by tissue necrosis
causes of eosinophilic leukocytosis
Allergies, parasitic infxn, hodgkin disease and some nonHL, collagen vascular disorders and some vasculitides, transient atheroembolic disease, drug reactions
causes of basophilic leukocytosis
rare, CML (chronic myelogenous leukemia)
causes of monocytosis
chronic infxn, bacterial endocarditis, rikettsiosis and malaria, IBD and collagen vascular disease
in a reactive lymphoid follicle with germinal center, you’ll see
tingible body MQ and mantle zone
Lymphoma
proliferation arising as discrete tissue masses, usually in LN
Hodgkin and NHL
Acute vs. chronic leukemia
Acute: if untreated, will kill a pt quickly because it’s very aggressive and made up of immature primitive cells
Chronic: progresses slowly over many years, then one day will transform into acute and pt will die quickly
Prognosis of acute vs. chronic leukemia
acute is more treatable than chronic because cells are dividing quickly
Acute affect more younger people while chronic affect the elder
Pathologic finding in AML
Auer rods can be seen in blasts
revised FAB classification of acute myelogenous leukemia
multiple myeloma
malignant neoplasm of plasma cells
WHO classification categories for hodgkin and NHL
precursor B-cell neoplasms (immature)
peripheral B-cell neoplasm (mature)
precursor T-cell neoplasm (immature)
Peripheral T-cell and NK neoplasm (mature)
Hodgkin lymphoma (neoplasm of Reed Sternberg cells)
Useful image
