Malformations of cortical development Flashcards
1
Q
What caused this?
A
periventricular nodular heterotopia (PVNH)
2
Q
How to differentiate Periventricular nodular heterotopia (5)
A
3
Q
What are these images showing
A
Focal cortical dysplasia:
Left: Thickened cortex (T2 FLAIR)
Right: concordant region of hypometabolism
4
Q
Patient with FCDs on MRI. What factors may suggest a genetic cause (and which gene)
A
X-linked FNLA (Filamin A)
More commonly Female
More commonly bilateral
5
Q
FCD classification:
- Why do we do it?
- Type I
- Type II:
- Type III
A
- More severe pathology has better prognosis (possibly due to being seen on MRI more easily
- Type I
- “mycrodysgenesis
- May not be seen on MRI
- Type II:
- Most severe
- Type IIb (baloon cells)
- Type III
- dual pathology
- associated with other lesions (such as mesial temporal sclerosis