Malformations of cortical development Flashcards

1
Q

What caused this?

A

periventricular nodular heterotopia (PVNH)

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2
Q

How to differentiate Periventricular nodular heterotopia (5)

A
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3
Q

What are these images showing

A

Focal cortical dysplasia:
Left: Thickened cortex (T2 FLAIR)
Right: concordant region of hypometabolism

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4
Q

Patient with FCDs on MRI. What factors may suggest a genetic cause (and which gene)

A

X-linked FNLA (Filamin A)
More commonly Female
More commonly bilateral

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5
Q

FCD classification:
- Why do we do it?
- Type I
- Type II:
- Type III

A
  • More severe pathology has better prognosis (possibly due to being seen on MRI more easily
  • Type I
    • “mycrodysgenesis
    • May not be seen on MRI
  • Type II:
    • Most severe
    • Type IIb (baloon cells)
  • Type III
    • dual pathology
    • associated with other lesions (such as mesial temporal sclerosis
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