AED Mechanisms of action Flashcards
Acetazolamide
Carbonic anhidrase inhibitor
Carbamazepine
Prevention of repetitive firing of Na
Also works on Ca L type channels
Clobazam
GABAa receptor agonist
Clonazepam
GABAa receptor agonist
Eslicarbazepine
Similar to CBZ, i.e., inhibition of voltage gated Na channels.
Ethosuximide
Reduces thalamic low-threshold T-type calcium currents in thalamic neurons.
Ezogabine
Potassium channel opener, particularly KCNQ2-5 channels
Felbamate
Inhibition of NMDA
Potentiation of GABAa receptor.
Gabapentin
Modulates voltage gated calcium channels.
Binds to the α2γ modulatory subunit of voltage-sensitive calcium channels
Lacosamide
Binds to collapsing response mediator protein 2 (CRMP-2), which is associated with neuronal outgrowth.
Enhances slow inactivation of voltage gated Na channels, resulting in stabilization of neuronal membranes.
Lamotrigine
Inhibition of voltage gated Na channels.
Inhibits high-voltage calcium currents (mediated by multiple channel types, N,P/Q,T-types).
Levetiracetam
Acts on the synaptic vesicle protein 2A (SV2A).
Inhibits N type Ca currents.
Oxcarbazepine
Metabolite MHD is a blocker of voltage-gated Na channel
Perampanel
Non competitive antagonist of AMPA receptors on post-synpatic neurons.
Phenytoin
Blockage of voltage-sensitive Na channels