Macular Degeneration drugs

Question 1

Name three drugs should to treat Macular Degeneration (VEGF Inhibitors)?

Answer 1

Pegatanib
Ranibizumab
Bevcizumab (associated with infection)
Aflibercept

Question 2

What are ADRs associated with Pegaptanib?

Answer 2

blepharitis, conjunctivitis, photopsia, bronchitis, diarrhea, dizziness, HA, nausea, UTI
Preg cat B
Cost: $800/dose

Question 3

What do we need to watch for when administering Pegaptanib?

Answer 3

Watch for endophthalmitis and increased IOP after injection.

Question 4

What are the ADRs asssociated with Aflibercept?

Answer 4

Conjunctival hemorrhage
Eye pain
Cataract
Floaters, vitreal detachment
Increased IOP

Question 5

What are the warning associated with Aflibercept?

Answer 5

Endophthalmitis
Increased IOP
Retinal detachment
Clots
Preg cat C
Cost: $1850/dose

Question 6

What is the purpose of polyethylene glycol to the drug molecule?

Answer 6

Decreases antigenicity
Increases molecule size to decrease renal clearance
Increases water solubility