Diuretics

Question 1

Name three Thiazides or Thiazide-like compounds

Answer 1

Chlorthalidone, Hydrochlorothiazide, Indapamide, Metolazone

Question 2

Name three ADRs for Thiazides

Answer 2

Hyponatremia, Hyperuricemia, Hypercalcemia, Hypokalemia, Orthostasis, Hyperglycemia, Hyperlipidemia, Mg deficiency, Torsades de pointes, Erectile dysfunction

Question 3

List three drug interactions for Thiazides

Answer 3

Quindine (Long QT),
Decreases effects (Anticoagulants, Uric acid agents, Sufonylureas, Insulin), Decreased by (NSAIDs, COX2, BAS) Increases effects (Anesthetics, Digoxin, Lithium, Loop diuretics, Vita. D),
Increased hypokalemia (Ampho B, Corticosteroids)

Question 4

Name three Loop Diuretics

Answer 4

Furosemide (Lasix), Bumetanide (Bumex), Torsemide (Demadex)

Question 5

What is the MOA for Thiazides

Answer 5

Blocks the transport of Na/Cl in the distal convoluted tubule which lowers the blood volume