M5 - Lesson 5: Uses of Enzymes Flashcards
How are enzymes used in Medicine?
- Most enzymes are confined within the cells of the body.
- However, small amounts of them can also be found in body fluids such as blood, urine, and cerebrospinal fluid.
- The level of ezyme activity in these fluids can easily be monitored.
This activity can prove extremely useful in Medicine: of particular enzymes in various body fluids signals the onset of certain diseases or their progression.
Abnormal activity (either high or low)
Disease Diagnosed: Hepatitis / Liver & kidney health condition
Normal Acitivity: 3-17 U/L
Enzyme: Alanine aminotransferase (ATP); Old name: Serum glutamic pyruvic transaminase (SGPT)
Disease Diagnosed: Prostate Cancer
Normal Acitivity: 2.5-12 U/L
Enzyme: Acid phosphatase
Disease Diagnosed: Liver or bone disease
Normal Acitivity: 13-38 U/L
Enzyme: Alkaline phosphatase (ALP)
Disease Diagnosed: Pancreatic disease
Normal Acitivity: 19-80 U/L
Enzyme: Amylase
Disease Diagnosed: Liver health or Heart attack
Normal Acitivity: 7-19 U/L
Enzyme: Aspartate aminotransferase (AST)
Disease Diagnosed: Liver health or Heart attack (Cerebrospinal fluid)
Normal Acitivity: 7-49 U/L
Enzyme: Serum glutamic oxaloacetic transminase (SGOT)
Disease Diagnosed: Heart Attack
Normal Acitivity: 100-350 WU/mL
Enzyme: Lactate dehydrogenate (LDH)
Disease Diagnosed: Heart Attack
Normal Acitivity: 7-60 U/L
Enzyme: Creatinine phosphate (CPK)
Disease Diagnosed: Heart Attack
Normal Acitivity: 15-75 U/L
Enzyme: Phosphohexose isomerase
When a heart attack occurs, some heart muscles are _______ and their enymes leak into the blood stream.
damaged/destroyed
Another name for aminotransferase is
transaminase
Two major advantages to manufacturing processes and in commercial products are:
Enzymes:
(1) cause very large increases in reaction rates even at room temperature;
(2) are relatively specific and can be used to target selected reactants.
Disadvantages are:
(1) Relative scarcity
2) Higher cost compared with traditional chemical treatments. (Remedied by genetic engineering
Digestive (Breakdown) Function
Hydrolases