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SBM > Lymphopoiesis > Flashcards

Lymphopoiesis Flashcards

0
Q

light cahins can establish

A

clontality in b cells

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1
Q

symptoms of lymphoma

A

local enlargement; typically non-tender
compression of adjacent structures
release of cytokines, producing sytsemic B symptoms

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2
Q

b cell lymphoma of follicular origin

A

monoclonal light chain, CD 19, CD20, CD5 pos, CD 10 neg

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3
Q

b cell small lymphocytic lymphoma

A

monoclonal light chain, CD 19, CD20, CD5, CD 23 pos, CD 10 neg

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4
Q

indolent lymphmas

A

Follicular
Marginal Zone
MALT

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5
Q

intermediate lymphoma

A

diffuse large cell

peripheral t cell

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6
Q

highly aggressive lymphoma

A

burkitt

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7
Q

4 types of classical hodgkins lymphoma

A

nodular sclerosing
lymphocyte predominant
mixed cellularity
lymphocyte depleted

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8
Q

most cases of lyphoma are not

A

familial

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9
Q

fatigue is NOT

A

a b symptom

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10
Q

LDH is a sign of

A

cell turnover in NHL

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11
Q

Ann Arbor Staging System

A

Stage 1- single lymph node on one side of diaphragm
Stage 2- 2+ on same side of diaphragm
Stage 3- lymphs on both sides of diaphragm
Stage 4- diffuse involvement of extralymphatic sites

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12
Q

IPI

A 
age >60
perf status (2-4- lower is better)
LDH level- elevated
extranodal involvement >1 site
stage (III-IV)
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13
Q

diffuse large cell lymphoma stage 1/2 cure

A

chemo and radiation

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14
Q

diffuse cell treatment stage III/IV

A

chemo only

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15
Q

CHOP

A

cyclophosphamide
doxorubicin
vincristine
prednisone

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16
Q

follicular lymphoma

A

slow dividing lymphocytes–>disease of slow accumulation due to defect apoptosis
increase in regulated BCL2–>anti-apoptic cells

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17
Q

grade 1 follicular lymphoma

A

small cleaved lymphocytes

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18
Q

treatment of follicular lymphoma

A

watch and wait

treat for symptoms!

19
Q

1/2a focciluclar

A

radiation only

20
Q

2B/3 follicular lymphoma

A

gentle chemo

CHOP w/o anthracyclin

21
Q

incurable

A

unless autologous stem cell or localized disease

22
Q

Marginal zone lymphomas

A

nodal marginal zone lymphoma
extramarginal zone lymphoma (MALT)
mantle cell lymphoma

23
Q

nodal marginal zone lymphoma

A

very similar presentation and course to follicular so treat like follicular

24
Q

extramarginal zone lymphoma

A

hpyloti; treat up to a year

25
Q

mantle cell lymphoma

A

aggressive; noncurable

t(11;14)–>cyclin D–>pushes cell through cell cycle

26
Q

Burkitt lymphoma

A

from germinal center- trans of MYC ongene–>persistnat expression–>constant replication

27
Q

treatment sporadic bburkitt cell lymphoma

A

intense, short,multi-agent chemo

28
Q

biggest progonostic factor if Hodgkins Lymphoma

A

PET scan negative after 2 treatments

29
Q

hodgkins lymphoma

A 
generalized adenopathy-->cervical/axillary
-above mediastinum
mediastinal mass
systemic symptoms
-B
-pruritis
-alcohol-induced pain
hepatosplenomegaly
30
Q

nodular lymphocyte predom

A

neck; young pts

popcorn cell

31
Q

classical hogdkins lymphoma

A

nodular sclerosis- most common
mixed cellularity- most aggressive- more RS, eosino, plasma, mono nuclear variant RS
lymphocyte rich
lymphocyte depleted- older patients, retroperitoneum, loss lympho, sclerosis, pleomorphic RS cell

32
Q

cRABi

A 
hypercalcemia
renal insufficiency
anemia
bone marrow lesions
infections
33
Q

multiple myeloma where does cell come from

A

post germinal

34
Q

cds for MM

A

cd38, cd138

35
Q

IG with worse prognosis

A

iga

36
Q

follicular markers

A

CD10
CD20
BCL2
t(14;18)

37
Q

DLCL

A

CD20
BCL2
BCL6

38
Q

Mantle cell

A

CD5
CD20
cyclin D1
t(11;14)

39
Q

marginal markers

A

CD20
t(11;18)
c-myc

40
Q

CLL/SLL markers

A

CD5
CD20
s/g dim CD23+

41
Q

CML

A

t(9;22)

42
Q

PV

A

Jak2

43
Q

AML

A

t (18;21)
Inv 6
T(16;17)

44
Q

poor prognosis AML

A

Del 5,7

complex CG

SBM (18 decks)

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