Hematopoiesis

Question 1

serum

Answer 1

plasma w/o clotting factor

Question 2

hematocrit

Answer 2

volume of plasma/volume of RBC

Question 3

HSC are typically in this phase

Answer 3

Gq; at any time only a few are actually giving rise to peripheral blood cells

Question 4

glycoprotein marker on HSC

Answer 4

CD34

Question 5

myeloid precursor cell gives rise to

Answer 5

platelets
monos
PMNs
RBCs

Question 6

lymphoid stem cells give rise to

Answer 6

NK lymphocytes
T lymphocytes
B lymphocytes

Question 7

where are stem cells developed

Answer 7

yolk sac–> @ 6 weeks liver/spleen–> @ 6/7 monthsbone marrow

Question 8

in adulthood, hematopoietic marrow confined to

Answer 8

axial skeleton and proximal ends of femurs

Question 9

in times of need what areas help out

Answer 9

fat in stem cell areas, liver, and spleen

Question 10

IL3

Answer 10

needed to go from stem cell to lymphoid OR myeloid stem cell

Question 11

SCF

Answer 11

this and IL3 needed to go from stem cell to myeloid precursor cell

Question 12

IL2

Answer 12

lympoid stem cell–>b lymp, t lymph, or NK cells

Question 13

just GM-CSF

Answer 13

myeloid precursor cell–>monos

Question 14

G-CSF & GM-CSF

Answer 14

myeloid precursor–>PMNs

Question 15

MCHC

Answer 15

average concentration of hemoglobin in a given volume of RBC

Question 16

MCV

Answer 16

average volume of RBCj

Question 17

RDW

Answer 17

coefficient of variation

increase in RDW= large variation in size

Question 18

causes of eosinophilia

Answer 18

Neoplasm
Asthma
Allergic processes
Collagen vascular diseases
Parasites

Question 19

bad thing about ILE

Answer 19

stimulates prolfiieration of AML blasts

Question 20

bad thing about G-CSF

Answer 20

stimulates proliferation and differentiation of WEHI3B myelomonocytic leukemia

increases prolferation of small cell carcinoma and colon carcinoma cell lines, L-60, and KG1

Question 21

other things G-CSF does

Answer 21

increases PMN phagocytossi and releases PMNs from bone marrow

Question 22

good things of GM-CSF

Answer 22

enhances cytotoxic and phagocytic actvty of PMNs, stimulates erythropoeisis in the presence of erythropoietin

Question 23

bad things GM-CSF

Answer 23

stmulates AML blasts to proliferate

prolfieration of small cell and colon carcinoma

Question 24

IL2 is a

Answer 24

growth factor for t cells

Question 25

IL1

Answer 25

actvates restng t cells
cofactor for t cell ad b cell prolfieration
induces producton of other growth factors
stmulates early myeloid cells