Hematopoiesis Flashcards
serum
plasma w/o clotting factor
hematocrit
volume of plasma/volume of RBC
HSC are typically in this phase
Gq; at any time only a few are actually giving rise to peripheral blood cells
glycoprotein marker on HSC
CD34
myeloid precursor cell gives rise to
platelets
monos
PMNs
RBCs
lymphoid stem cells give rise to
NK lymphocytes
T lymphocytes
B lymphocytes
where are stem cells developed
yolk sac–> @ 6 weeks liver/spleen–> @ 6/7 monthsbone marrow
in adulthood, hematopoietic marrow confined to
axial skeleton and proximal ends of femurs
in times of need what areas help out
fat in stem cell areas, liver, and spleen
IL3
needed to go from stem cell to lymphoid OR myeloid stem cell
SCF
this and IL3 needed to go from stem cell to myeloid precursor cell
IL2
lympoid stem cell–>b lymp, t lymph, or NK cells
just GM-CSF
myeloid precursor cell–>monos
G-CSF & GM-CSF
myeloid precursor–>PMNs
MCHC
average concentration of hemoglobin in a given volume of RBC
MCV
average volume of RBCj
RDW
coefficient of variation
increase in RDW= large variation in size
causes of eosinophilia
Neoplasm Asthma Allergic processes Collagen vascular diseases Parasites
bad thing about ILE
stimulates prolfiieration of AML blasts
bad thing about G-CSF
stimulates proliferation and differentiation of WEHI3B myelomonocytic leukemia
increases prolferation of small cell carcinoma and colon carcinoma cell lines, L-60, and KG1
other things G-CSF does
increases PMN phagocytossi and releases PMNs from bone marrow
good things of GM-CSF
enhances cytotoxic and phagocytic actvty of PMNs, stimulates erythropoeisis in the presence of erythropoietin
bad things GM-CSF
stmulates AML blasts to proliferate
prolfieration of small cell and colon carcinoma
IL2 is a
growth factor for t cells
IL1
actvates restng t cells
cofactor for t cell ad b cell prolfieration
induces producton of other growth factors
stmulates early myeloid cells
