Intro to WBC

Question 1

Absolute Neurtrophil Count

Answer 1

ANC= WBC x (%PMN + %bands)

Question 2

leukocytosis

Answer 2

total WBC elevated above normal range

Question 3

band news

Answer 3

immature neutrophil

Question 4

patterns of leukocytosis/neutrophilia

Answer 4

shift neutrophila
left shift
leukemoid rxn
leukoerythroblastic rxn
leukemia

Question 5

shift neutrophilia

Answer 5

demargination of marginal pool w/o proliferation

moderate in degree, rapid onset

Question 6

shift neutrophilia generally seen with

Answer 6

steroids
epi injection
stress
seizures

Question 7

left shift

Answer 7

more bands and occasional metamyelocyte in periphery

Question 8

leukemoid rxn

Answer 8

demargination and marrow proliferation
–increase in both mature and immature forms–>
involves a left shift

Question 9

leukemoid rxn seen w/

Answer 9

infection, inflammation, metastatic cancer, G-CSF

Question 10

leukoerythroblastic rxn

Answer 10

seen w/ damaged bone marrow causing premature release of precursors cells

Question 11

you may see this cell in a leukoerythroblastic rxn

Answer 11

tear drop cells

Question 12

neutropenia

Answer 12

an absolute PMN count below normal range 2200-7000 cells/ul

Question 13

congenital causes of neutropenia

Answer 13

cyclic neutropenia (autosomal dominant)
severe congenital neutropenia (auto dom)
kostmann syndrome (auto recessve)

Question 14

acquired causes of neutropenia

Answer 14

infection
drug/toxin
nutritional deficiencies
neoplasm
hypersplenism/splenomegaly
immune-induced

Question 15

ANC no significant risk for infection

Answer 15

1000-1500

Question 16

ANC some increased risk, fever managed as outpatient

Answer 16

500-1000

Question 17

ANC significantly increased risk of infection- cut off for antibiotics/hospitalization

Answer 17

<500

Question 18

ANC severe risk fungal & opportunistic infection

Answer 18

ANC <200