Lymphoma/Leukemia Flashcards
1
Q
Hodgkin’s Lymphoma
A
- reed-sternberg cells (giant cells)
- no known cause, begins above diaphragm
- 15 to 35 yrs, > 50 yrs
- more common in men
2
Q
Hodgkin’s RF & D
A
- Epstein-Barr virus
- genetics
- toxins
- hyperplasisa
- D: presence of Reed-Sternberg Cells
3
Q
Hodgkin’s Manifestations
A
- insidious onset
- enlargement of cervical, axillary, or inguinal nodes
- movable, painless, & nontender nodes
- B symptoms: fever, night sweats, weight loss (worse prognosis)
4
Q
Mediastinal Involvement Signs
A
- cough
- dyspnea
- stridor
- dysphagia
5
Q
Hodgkin’s Advanced Cases
A
- hepatomegaly
- splenomegaly
- anemia
6
Q
Hodgkin’s D
A
- blood analysis
- biopsy
- bone marrow exam
- radiologic evaluation
7
Q
HL Chemo
A
Favorable early-stage disease, receive 2 to 4 cycles
Unfavorable early stage, receive 4 to 6 cycles
Advanced stage, receive 6 to 8 cycles
8
Q
NHL
A
- affects all ages
- B & T cell origin
- unknown cause
- in those who had chemo/radiation or immunosuppressive drugs
9
Q
NHL Manifestions
A
- can originate outside nodes
- painless node enlargement
- high grade: lymphadenopathy & B symptoms
10
Q
Which lymphoma has worse prognosis?
A
NHL
11
Q
Leukemia
A
A group of malignant disorders affecting the blood and blood-forming tissues of
Bone marrow
Lymph system
-no single cause
12
Q
Leukemia Acute vs Chronic
A
- A: Clonal proliferation of immature hematopoietic cells
- C: Mature forms of WBC, and onset is more gradual
13
Q
AML
A
- adults
- abrupt, dramatic onset: infection or bleeding
- hyperplasia
14
Q
ALL
A
- children
- B cell
- fever, bleeding
- insidious with progressive weakness, pain, bleeding
- CNS
15
Q
CML
A
- bone marrow (move to blood)
- infiltrate liver/spleen
- Philadelphia Chromosome
- chronic stable phase Followed by acute, aggressive (blastic) phase
