Lymphoma: Krafts

Question 0

In a lymph node, where do B cells reside? T cells?

Answer 0

B cells: Follicles

T cells: Intergerminal centers

Question 1

Most overall common cause of lymphadenopathy:

Answer 1

Benign reaction to infection

Question 2

What are the cells that clear debris from normal lymph nodes?

Answer 2

Tingible body macrophage

Question 3

If you biopsy a lymph node and find large, irregular follicles with varied cells and tingible bodies, what is the diagnosis?

Answer 3

Benign Follicular Hyperplasia

Question 4

What is meant by partial effacement and what does it indicate?

Answer 4

Node is not completely replaced by the germinal centers.

If you can’t find germinal centers, likely malignant

Question 5

What type of spreading pattern does Non-hodgkin’s lymphoma have?

Answer 5

Skips around

Question 6

What do lymph nodes feel like in NH lymphoma?

Answer 6

Firm, but not rock hard

Question 7

What are the B symptoms to lymphoma?

Answer 7

Night sweats, weight loss, fever

Question 8

What is the cellular morphology of low grade NH lymphoma? High grade?

Answer 8

Low grade: Mature, small cells

High grade: Big, ugly cells

Question 9

Small lymphocytic lymphoma is the same as…

Answer 9

Chronic lymphocytic leukemia

Question 10

What cells and what unique genetic markers are present in SLL?

Answer 10

B cells with CD5+

Question 11

What is the name of the transformation into large cells that makes mortality increase substantially from SLL?

Answer 11

Richter transformation

Question 12

MALT lymphoma is a type of _______ lymphoma

Answer 12

Marginal zone

Question 13

This bacterium is associated with marginal zone lymphoma

Answer 13

H. pylori

Question 14

What does a marginal zone lymphoma lymphocyte look like in the blood?

Answer 14

More cytoplasm than usual

Question 15

What cytogenetic abnormality is associated with Mantle Cell Lymphoma and what is the resulting protein problem?

Answer 15

t(11:14), Cyclin D1 overexpressed via IgH expression

Question 16

Follicular lymphoma is graded via what characteristic?

Answer 16

Small cleaved cell, mixed, or large cell

Question 17

What genetic abnormality leads to follicular lymphoma and what is the cellular manifestation?

Answer 17

t(14:18), bcl-2 increased by put next to IgH

Question 18

Butt cells are seen in…

Answer 18

Follicular lymphoma

Question 19

Paratrabecular aggregates are seen in…

Answer 19

Follicular lymphoma

Question 20

What is the lymphoma that presents as skin lesions?

Answer 20

Mycosis fungoides/Sezary syndrome

Question 21

What do cells look like with Mycosis fungoides/Sezary syndrome?

Answer 21

Cerebriform lymphocytes

Question 22

What cells are the problem under Mycosis fungoides?

Answer 22

T cells

Question 23

Diffuse large cell lymphoma involves what cells?

Answer 23

B cells

Question 24

Does diffuse large cell lymphoma have a good or bad prognosis?

Answer 24

Bad

Question 25

Lymphoblastic lymphoma is also known as

Answer 25

Acute lymphocytic leukemia

Question 26

How does lymphoblastic lymphoma present?

Answer 26

Teenage male with mediastinal mass

Question 27

What is the genetic abnormality of Burkitt's lymphoma? What about the problem that results?

Answer 27

t(8,14), c-myc expressed at high levels due to being next to IgH

Question 28

What does Burkitt's lymphoma look like on a patient?

Answer 28

Large, fast growing masses extranodally

Question 29

What cells do you see in a burkitt's lymphoma cellular mass?

Answer 29

tingible bodied macrophages

Question 30

What is unique about how the CELLS look in Burkitt's lymphoma?

Answer 30

Blue cytoplasm

Question 31

Where (geography) does Adult T Cell Lymphoma present?

Answer 31

Japan and caribbean

Question 32

What causes Human T cell lymphoma?

Answer 32

HTLV-1

Question 33

What are some common clinical findings in HTL?

Answer 33

skin lesions, hypercalcemia

Question 34

Hodgkin's lymphoma has a unique cell called ______ that looks like _______.

Answer 34

Reed-Sternberg cell, owl eyes

Question 35

Who is at highest risk of getting Hodgkin's lymphoma?

Answer 35

Young men and elderly

Question 36

How does Hodgkin's lymphoma spread?

Answer 36

Pretty linearly

Question 37

What is the nature of the cells surrounding Reed-Sternberg cells?

Answer 37

Reactive. Not malignant

Question 38

What is a unique histological feature of Nodular L-P Hodgkin's lymphoma?

Answer 38

Popcorn cells

Question 39

What is the usual presenting patient with Nodular L-P Hodgkin's lymphoma?

Answer 39

Teenage male with cervical lymphadenopathy

Question 40

What is the prognosis for Nodular L-P Hodgkin's lymphoma?

Answer 40

Good

Question 41

What is the most common subtype of Hodgkin's lymphoma where you see lacunar cells?

Answer 41

Nodular sclerosis Hodgkin's lymphoma

Question 42

Which Hodgkin's lymphoma subtype has a poor prognosis and you see a mixture of background cells?

Answer 42

Mixed cellularity Hodgkin's Lymphoma

Question 43

In this type of Hodgkin's lymphoma, the background has collagen and reticulin.

Answer 43

Lymphocyte depletion HL