Immunosuppressants

Question 0

Glucocorticoid use results in an increase in ________ cells but a decrease in these cells:

Answer 0

Neutrophils;
T & B lymphocytes
Monocytes
Eosinophils
Basophils

Question 1

These interfere with the distribution and function of IL-2 and TNF-a.

Answer 1

Prednisone and Dexamethason

Question 2

When used as an antineoplastic, how is dosing for glucocorticoids different as when using as an immunosuppressant?

Answer 2

High dose PULSE for antineoplastic

Low dose, continuous for immunosuppressant

Question 3

What two drugs act in inhibiting calcineurin?

Answer 3

Cyclosporine, tacrolimus

Question 4

Decreasing calcineurin activity leads to the decrease of what cytokine?

Answer 4

IL2

Question 5

What are the three drugs that target CD20?

Answer 5

Rituximab
Ibritumomab
Tositumomab

Question 6

What antibody drug targets CD52?

Answer 6

Alemtuzumab

Question 7

What is the method of action of Denileukin diftitux?

Answer 7

It’s an IL2 with diphtheria toxin attached to it. It kills cells with activated IL2 receptors

Question 8

What three cytokines have been used for immune system stimulants?

Answer 8

IFNa, TNFa, IL-2

Question 9

What is the product that is decreased by IFNa?

Answer 9

FGF (fibroblast growth factor)

Question 10

What are the five hematopoietic agents we need to know?

Answer 10

Erythropoietin
Filgrastim
Sogrimostim/Romiplostim
IL-11