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IHO Week 4 > Angiogenesis Drugs > Flashcards

Angiogenesis Drugs Flashcards

0
Q

Unique side effects of IL12

A

Thrombocytopenia, leukopenia, anemia

Liver problems, stomatitis

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1
Q

IL-12 induces ______ which activates ______ which causes an anti-angiogenic response

A

IFNg, Inducible protein 10

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2
Q

IFNa works by three mechanisms. What are they?

A

Decreases FGF (angiogenic)
Inhibits all cell division
Increases MHC I expression on tumor cells

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3
Q

What is a unique side effect to IFNa?

A

Depression

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4
Q

What is the protein necessary for angiogenesis when it senses nutrients are low?

A

mTOR

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5
Q

What is the receptor that activates mTOR?

A

VEGF-R

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6
Q

What is the humanized monoclonal antibody directly targeting VEGF?

A

Bevacizumab

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7
Q

Along with 5FU, Bevacizumab has been approved for treatment for which cancers?

A

Metastatic colon cancer, lung cancer, breast cancer

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8
Q

Bevacizumab has also been approved for which non-malignant diseases?

A

Macular degeneration and diabetic neuropathy

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9
Q

What are the unique side effects of Bevacizumab?

A

Wound dehiscence, GI perforation, and hemoptysis

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10
Q

These three drugs are inhibitors of VEGF-R and PDGF-R

A

Pazopanib, Sorafenib, Sunitinib

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11
Q

Pazopanib and sunitinib also block this important protein.

A

c-KIT

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12
Q

What cancer in particular do Pazopanib, Sorafenib, and sunitinib treat?

A

Renal cell carcinoma

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13
Q

What enzyme metabolizes these three drugs?

A

CYP3A4

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14
Q

What are some unique side effects for Pazopanib, Sorafenib, and Sunitinib?

A

Congestive heart failure, AMI, teratogenic

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15
Q

What two drugs are mTOR inhibitors?

A

Everolimus, Temsirolimus

16
Q

What two important cell cycle proteins does mTOR regulate translation of?

A

Cyclin D1 and p21

17
Q

What is the mode of resistance to Everolimus and Temsirolimus?

A

p-Glycoprotein

18
Q

What are Everolimus and Temsirolimus metabolized by?

A

CYP 3A4

19
Q

What specific cancer are mTOR inhibitors used for?

A

Renal cell carcinoma

20
Q

Everolimus and Temsirolimus are uniquely toxic in these 4 ways:

A

Hypersensitivity reactions
Angioedema
Kidney arterial and venous thrombosis
Increased risk of lymphomas and infection

21
Q

What’s the name of the “birth defect drug” and what is it used for?

A

Thalidomide, suppresses immune and inflammatory reactions and angiogenesis inhibitor

22
Q

Thalidomide is the most effective anti-_____ agent known

A

TNF

23
Q

What are the two approved diseases treated by thalidomide?

A

Multiple myeloma and Hansen’s disease

IHO Week 4 (11 decks)

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