Drug Targets Flashcards by Jay Allen

Q

Rituximab

A

CD20

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Q

Cetuximab/Panitumomab

A

EGFR

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Q

Ibritumomab

A

CD20

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Q

Tositumomab

A

CD20

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Q

Everolimus/Temsirolimus

A

mTOR

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Q

Prednisone/Dexamethasone

A

Decrease IL2 and TNFa

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Q

IL12

A

Stimulates IFNg

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Q

Bevacizumab

A

VEGF

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Q

Pazopanib/Sorafenib/Sunitinib

A

STI, multiple kinases especially VEGF and PDGF

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Q

Trastuzumab

A

Her2

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Q

Lapatinib

A

Her2, EGFR, STI

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Q

Imatinib

A

BCR-ABL (STI)

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Q

Vorinostat

A

HDAC

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Q

Bortezomib

A

26S proteosome

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Q

L-asparaginase

A

Treat childhood ALL

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Q

Tretinoin

A

APL treatment

Q

Arsenic trioxide

A

Promotes Apoptosis

Approved for relapsed APL

Q

Bexarotene

A

It’s a rexinoid, activates receptors involved with cell growth

Q

IFNa

A

Decrease FGF

Q

Cyclosporine tacrolimus

A

Cyclophilin, FK binding protein

Decrease NF, Decrease IL2

Q

Denileukin diftitux

A

IL2 receptor

Q

Alemtuzumab

A

Changes target protein CD52