B Cell maturation Flashcards
( With regards to TdT and B220) Intermediate Pro-B cells express:
TdT and B220
( With regards to TdT and B220) Early Pro-B cells express:
TdT alone
(With regards to TdT and B220) Late pro-B cells express:
B220 and downregulated TdT
What is the purpose of B220?
Receptor for cell growth and differentiation
At what point do B cells start to produce CD43 (leukosialin), CD19, RAG-1 and RAG-2.
Pro-B
What is CD19?
BCR Coreceptor
As B cells change from pro-B to pre-B, they downregulate…
TdT, RAG 1 and 2, CD43
What induces Pro-B to turn into Pre-B cells?
c-Kit
What stimulates pre-B cells to differentiate and proliferate?
IL-7
At what stage is the light chain produced?
Immature B cell
What is the cytokine that is important for survival of pre-immune B cells from transition stage onward?
Blys
What are the three cytokines important for B cell differentiation?
IL-3, IL-4, L-BCGF
Immunodeficiency XLA is the result of a defect in what kind of protein?
Bruton’s tyrosine kinase
Does positive or negative selection come first in B cell transition?
Negative first, then positive
What type of B cell will become plasma or memory cells?
Follicular B cells
What type of B cells respond to T cell dependent antigens?
B-1 B cells
B-1 cells never start to make…
IgG
An antigen that activates both T and B cells is called a…
TD antigen: T dependent Antigen
An antigen that activates only B cells is called a…
TI antigen: T independent antigen
What type of antibodies are produced in a TI type 1 antigenic response?
IgM
What receptors does lipopolysaccharide (a TIA type 1) bind on a B cell?
BCR and TLR4
Type 2 TI antigens usually bind several ______ at once.
BCR’s
