Antigen Presenting and Processing Flashcards
What T cell receptor binds to B7 in order to activate it? To inactivate it?
CD28
CTLA-4
What needs to bind to a T cell in order for it to become activated?
MHC and B7
What are the T cell molecules involved in the immunological synapse? (5)
CD28 CD4/8 TCR CD2 LFA-1
What is the process where a T cell binds to an MHC but no other receptor, resulting in inactivation or cell death?
Anergy
Over time, T cells express this receptor, leading to cell death if bound with B7.
CTLA-4
Which APC constitutively presents B7?
Dendritic cells
What are macrophages activated by?
Phagocytosis of foreign antigen
cytokines
Macrophages present _______ antigens, whereas B cells present ________ antigens.
Particulate
soluble
What is the only type of T cell that is only activated by Dendritic cells?
naive T cells
What is it that causes a constitutive proteasome to convert into an immunoproteasome?
TNFa and IFNg
What complex is responsible for the peptides to be transported into the RER?
TAP1 and TAP2
What is the optimal size of peptide for MHC?
9 amino acids
What protein bridges TAP and MHC?
TPS
What protein does the excess clipping of peptides and where?
ERAAP, in RER
What is the purpose of Calnexin?
Ensures correct protein folding
