Lymphoma

Question 1

What is the most common hematopoietic malignancy in cats and dogs?

Answer 1

Lymphoma

Question 2

What are risk factors for lymphoma in cats?

Answer 2

FeLV, immune suppression (FIV), chronic inflammation

Question 3

What cat breeds are somewhat predisposed to lymphoma?

Answer 3

Siamese and oriental breeds

Question 4

How does FeLV predispose to lymphoma?

Answer 4

Direct role in DNA mutation causing lymphoma

Question 5

How is lymphoma usually classified in cats?

Answer 5

By its anatomic location

Question 6

What is the most common site for lymphoma in cats?

Answer 6

GI

Question 7

Lymphoma presenting similar to IBD is usually what grade?

Answer 7

Low grade, small cell, lymphocytic

Question 8

What are clinical signs of low grade lymphoma in cats?

Answer 8

Chronic wt loss, low appetite, V+/D+

Question 9

How will intestines of a low grade lymphoma cat appear on ultrasound?

Answer 9

Diffuse thickening

Question 10

What is the prognosis for a low grade GI lymphoma in cats?

Answer 10

Guarded to good (survival time can be several years in some cases)

Question 11

How do you treat a low grade GI lymphoma in cats?

Answer 11

Prednisolone and chlorambucil

Question 12

What is high grade GI lymphoma?

Answer 12

Large cell, lymphoblastic

Question 13

How will intestines of a high grade lymphoma cat appear on ultrasound?

Answer 13

Discrete masses or severe thickening

Question 14

How do you treat high grade GI lymphoma in cats?

Answer 14

CHOP/COP chemotherapy

Question 15

What is the MST for high grade GI lymphoma in cats if treated with chemotherapy?

Answer 15

6-8mo

Question 16

Is mediastinal lymphoma in cats usually high or low grade?

Answer 16

High grade

Question 17

What structures does mediastinal lymphoma affect in cats?

Answer 17

Thymus and sternal LNs

Question 18

What are clinical signs of mediastinal lymphoma in cats?

Answer 18

Resp distress, pleural effusion

Question 19

How common is nodal/multicentric lymphoma in cats?

Answer 19

Less common than in dogs

Question 20

How common is nodal/multicentric lymphoma in dogs?

Answer 20

Most common form in dogs

Question 21

What is Hodgkin’s-like lymphoma in cats?

Answer 21

Single or regional LNs involved @ head and neck

Question 22

Where does renal lymphoma metastasize to in cats?

Answer 22

CNS

Question 23

Is renal lymphoma in cats more often uni- or bilateral?

Answer 23

Bilateral

Question 24

How does a nasal lymphoma present in cats?

Answer 24

Sneezing, epistasis, nasal discharge, and facial deformity

Question 25

How do you treat a nasal lymphoma in a cat?

Answer 25

Radiation therapy

Question 26

How do you diagnose lymphoma?

Answer 26

FNA, biopsy

Question 27

What chemotherapy protocol is thought to be most effective for treating high grade lymphoma in cats and dogs?

Answer 27

CHOP, L-CHOP, COP

Question 28

What chemotherapy agents are involved in CHOP protocols?

Answer 28

``` L = L-asparaginase C = Cyclophosphamide H = Doxorubicin O = Vincristine P = Pred ```

Question 29

What is the best way to determine prognosis of a lymphoma in cats?

Answer 29

Response to therapy

Question 30

Is lymphoma phenotype prognostic in cats?

Answer 30

No

Question 31

What is the most common type of canine lymphoma?

Answer 31

Lymphoblastic high grade

Question 32

What is the most common distribution of canine lymphoma?

Answer 32

Nodal/multicentric

Question 33

What are presenting complaints that bring dogs to the clinic?

Answer 33

"Bumps", lethargy

Question 34

Other than LNs, what other organs are commonly enlarged with lymphoma?

Answer 34

Liver and spleen

Question 35

How big is a lymphoblast?

Answer 35

2-3x size of RBC

Question 36

Which canine lymphoma phenotype carries a better prognosis?

Answer 36

B-cell

Question 37

What % of multicentric canine lymphomas are B-cell?

Answer 37

80%

Question 38

Lymphomas that cause hypercalcemia are which phenotype?

Answer 38

T-cell

Question 39

What mediates hypercalcemia caused by T-cell lymphomas in dogs?

Answer 39

Production of PTH related peptide

Question 40

How is GFR affected by hypercalcemia related to T-cell lymphomas?

Answer 40

Isosthenuria

Question 41

How many stages of canine lymphoma are there?

Answer 41

5

Question 42

Single LN involved

Answer 42

Stage 1

Question 43

Multiple LNs involved on same side of diaphragm

Answer 43

Stage 2

Question 44

Multiple LNs involved on both sides of the diaphragm

Answer 44

Stage 3

Question 45

Liver and/or spleen involvement

Answer 45

Stage 4

Question 46

Blood, BM, other organ involvement

Answer 46

Stage 5

Question 47

What are canine lymphoma substages?

Answer 47

A (clinically well) and B (clinically ill)

Question 48

What is the MST for lymphoma dogs treated with CHOP chemo?

Answer 48

1y

Question 49

What is the MST for lymphoma dogs treated with prednisone alone?

Answer 49

A few months

Question 50

What is the MST for dogs with lymphoma that do no undergo any treatment?

Answer 50

2-4wk