Lymphoma

Question 1

Types of Lymphoma (architecture)

Answer 1

Diffuse
nodular/follicular –> no mantle zone or germinal centers / bcd-2 +
appearance of cells –> based on cellular maturity

Question 2

high grade lymphoma (working formula)

Answer 2

resembles acute leukemia
can cure
can die quickly if not cured
Large Cell Immunoblatic / Burkitts (small non-cleaved cell)

Question 3

low grade lymphoma (working formula)

Answer 3

resembles chronic leukemia
cannot cure
smolders for years
SLL / Follicular lymphoma

Question 4

Types of Lymphomas (WHO)

Answer 4

precursor B
periph B
precursor T
periph T
NHL

Question 5

Marginal Zone lymphoma

Answer 5

MALToma
assoc w/ ongoing autoimmune process
H. pylori –> adenoCa and MALT lymphoma
low grade can be cured surgically

Question 6

NHL

Answer 6

multiple periph nodes
noncontiguous spread
Waldeyer ring and mesenteric nodes commonly involved
extranodal involvement common

Question 7

Hodgkin Lymphoma

Answer 7

localized to single axial group of nodes
orderly spread
mesenteric nodes and Waldeyer ring rarely involved
extranodal involvement uncommon