Acute Leukemia

Question 1

Leading cause of cancer deaths in children

Answer 1

acute leukemias

Question 2

Acute Leukemias

Answer 2

malig neoplasms of hematopoietc stem cells
primary disorders of bone marrow
fatal within weeks if left untreated
immature blast cells in periph smear

Question 3

Blast crisis

Answer 3

xsformation of a chronic leukemia into an acute one

Question 4

ALL blasts

Answer 4

no Auer rods
TdT+ –> terminal deoxynuclear xsferase
will have some lymphocytic markers

Question 5

AML blasts

Answer 5

Auer rods
myeloid markers
peroxidase +
sudan black +

Question 6

pre B cell ALL

Answer 6

common
Ig gene rearrangement
CALLA antigen –> better prognosis

Question 7

T cell ALL

Answer 7

Tcell surface markers
older children / young adults
mediastinal or CNS involvement
poorer prognosis than CALLA + ALL
leukemic phase of lymphoblastic lymphoma

Question 8

B cell ALL

Answer 8

cytoplasmic immunoglobulin
L3 morphology
leukemic phase of Burkitt’s lymphoma
poorer prognosis than CALLA + ALL

Question 9

Good ALL prognostic indicators

Answer 9

hyperdiploidy

t(12;21)

Question 10

Poor ALL prognostic indicators

Answer 10

t(9;22), abl-bcr

Question 11

ALL L1

Answer 11

small cells predominate
nuclei are round with occasional clefts
nucleoli are not visible
homogenous

Question 12

ALL L2

Answer 12

heterogenous
nuclei often show clefts
nucleoli are present

Question 13

ALL L3

Answer 13

homogenous pop of large cells
round nuclei
prominent nucleoli
deeply basophilic and abundant cyto

Question 14

t(8;21)(q22;q22)

Answer 14

AML ETO

Question 15

t(15;17)(q22;q11-12)

Answer 15

promyelocytic leukemia

Question 16

inv(16)(q13q22) or t(16;16)(q13;q11)

Answer 16

AML w/ abnormal bone marrow eosinophils

Question 17

11q23

Answer 17

AML w/ MLL abnormalities