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Systemic Pathology 2018 > Lymphoid Images > Flashcards

Lymphoid Images Flashcards

1
Q

What organ is this?

A

Normal thymus

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2
Q

What organ is this?

A

Normal thymus

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3
Q

Name this region of the thymus

A

Cortex

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4
Q

Name this region of the thymus

A

Medulla

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5
Q

Name this structure and region within the thymus. What types of cells is this structure comprised of?

A

Hassall’s corpuscle within the medulla - comprised of thymic epithelial cells that contain coiled layers of keratin

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6
Q

Which region of the thymus is rich in T cells?

A

Medulla

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7
Q

Name this pathologic process and etiology

A

Thymic atrophy due to parvovirus

Other causes: viral, glucocorticoids, nutritional deficiency, toxins

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8
Q

Name this pathologic process and etiology

A

Thymic enlargement = thymoma

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9
Q

This is a histologic image of a thymoma. What is the main cell type?

A

Epithelial cells

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10
Q

What organ is this?

A

Normal spleen

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11
Q

What organ is this? ID the red, purple and pink areas.

A

Spleen

Red = red pulp

Purple = white pulp

Pink = fibrous capsule

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12
Q

What organ is this? ID the purple and red regions. What do these regions supply?

A

Spleen

Red = red pulp = RBC, macrophages (vascular)

Purple = white pulp = B and T cells (lymphoid)

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13
Q

Name the pathologic process and etiology

A

Uniform splenomegaly due to congestion

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14
Q

Name the pathologic process and etiology

A

Uniform splenomegaly due to septicemia

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15
Q

Name the pathologic process and etiology

A

Splenomegaly due to histoplasmosis

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16
Q

Name the pathologic process and morphologic dx?

A

Splenomegaly with chronic diffuse granulomatous splenitis

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17
Q

Name the etiology

A

Hemangioma

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18
Q

Name the pathologic process and etiology

A

Splenic nodule

Hemangioma

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19
Q

Name the pathologic process and etiology

A

Splenic nodule

Hemangiosarcoma

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20
Q

This is from a splenic nodule. What is the likely etiology?

A

Hemangiosarcoma

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21
Q

Name the pathologic process and etiology

A

Splenic nodules/masses

Hemangiosarcoma

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22
Q

Name the pathologic process and etiology

A

Splenic nodule

Splenic infarct with thrombus

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23
Q

Name the pathologic process and etiology

A

Splenic nodular hyperplasia

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24
Q

This is a histopath image from the spleen. Name the etiology.

A

Splenic nodular hyerplasia

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25
Name the pathologic process and etiology
Splenic nodules/mass Splenic metastatic carcinoma
26
Name the pathologic process and etiology
Splenic nodules Splenic siderotic plaques Common in old dogs
27
Splenic rupture
28
What organ is this?
Normal lymph node
29
Name this region of the lymph node. What does it contain?
Cortex Follicles with B cells
30
Name this region of the lymph node
Medulla
31
Name this region of the lymph node. What is the predominant cell here?
Medullary cord Plasma cells Increase with immune stimulation
32
Label the areas of the lymph node. What do each of these areas do/contain?
* Capsule = fibrous connective tissue * Subcapsular sinus = space that receives afferent lymph * Parafollicular zone = densely cellular area between follicles and medulla – contains T cells * Medullary sinuses = spaces containing macrophages and small lymphocytes – number of macrophages will increase when inflammation occurs
33
What is this staining for in the lymph node?
B cells stain brown – in follicular and medullary cords T cells stain red – in parafollicular zone
34
Lymph node
35
Lymph node
36
Name the pathologic process and etiology. What are the causes?
Lymphadenomegaly/lymphadenopathy **Lymphadenitis** Causes: infectious, immune, toxic etiology
37
Give the morphologic diagnosis.
Acute suppurative and hemorrhagic lymphadenitis
38
Give the morphologic diagnosis.
Acute suppurative and hemorrhagic lymphadenitis Note: lymphotes, necrotic cells
39
Name the pathologic process, etiology and duration
Lymphadenomegaly/lymphadenopathy Lymphadenitis Chronic (more remodeling)
40
Name the pathologic process, etiology and causes
Lymphadenomegaly/lymphadenopathy **Lymphoid hyperplasia** Causes: Ag stimulation, viral infection - Malignant catarrhal fever, BLV, FIV
41
Name the pathologic process, etiology and causes
Lymphadenomegaly/lymphadenopathy **Lymphoid hyperplasia** Causes: Ag stimulation, viral infection - Malignant catarrhal fever, BLV, FIV
42
Name the pathologic process and etiology
Lymphadenomegaly/lymphadenitis ## Footnote **Lymphoma**
43
Name the pathologic process and etiology
Lymphadenomegaly/lymphadenitis ## Footnote **Lymphoma**
44
Name the pathologic process and etiology
Lymphadenomegaly/lymphadenitis ## Footnote **Lymphoma**
45
Name the pathologic process and etiology
Lymphadenomegaly/lymphadenitis ## Footnote **Multicentric Lymphoma in dogs**
46
Name the organ and disease
Liver Lymphoma
47
Name the organ and disease
Spleen Lymphoma with siderotic plaques
48
Name the disease and distribution. This is the most common form in this species
Alimentary lymphoma in cats
49
Name the disease and species
Lymphoma in cats
50
Name the disease and species
Lymphoma in cats
51
Name the disease and species
Lymphoma in cats
52
Name the disease and species
Lymphoma in cats
53
Name the disease and species
Lymphoma in cats
54
Name the disease and species
Lymphoma in cats
55
56
Name the disease and species
Lymphoma in cats
57
Name the distrubution, disease and species
Alimentary lymphoma in cats
58
Name the distrubution, disease and species
Alimentary lymphoma in cats
59
Name the disease and species
Lymphoma in cattle
60
61
Name the distribution, disease and species
Multicentric lymphoma in cattle Abomasum
62
Name the distribution, disease and species
Multicentric lymphoma in cattle Right atrium
63
Name the distribution, disease and species
Calf lymphoma in cattle Bone marrow
64
Name the distribution, disease and species
Multicentric lymphoma in cattle Spinal epidural fat
65
Name the pathologic process and etiology
Lymph node atrophy due to canine distemper virus Note: reduced number of cell density, # of lymphocytes, normal structures not discernable
66
Lymph node atrophy due to distemper virus. What is missing?
Medullary cords
67
* Dog presented with enlarged LN, splenomegaly, neuro signs: collapse, weakness * Necropsy: generalized LN enlargement, hepatomegaly, splenomegaly * LN were large, off-white on cut surface, loss of cortex and medulla * Name the distribution and disease
Multicentric lymphoma
68
This is multicentric lymphoma in a dog. What are some notable histological features that confirm this diagnosis?
* Loss of normal architecture * Monomorphic medium-sized lymphocytes * Lymphocytes extend beyond capsule into perinodal tissue * Lymphocytes have coarse, marginated chromatin, prominent nucleoli, mild anisocytosis/anisokaryosis and frequent mitotic figures
69
* Dog presented with enlarged LN, splenomegaly, neuro signs: collapse, weakness * Necropsy: generalized LN enlargement, hepatomegaly, splenomegaly * LN were large, off-white on cut surface, loss of cortex and medulla * Name the organ, distribution and disease. * Which areas are expanded?
Multicentric lymphoma Expanded white pulp areas contain medium sized lymphocytes
70
This is a lymph node. Give the morphologic diagnosis.
Chronic pyogranulomatous lymphadenitis
71
This is a lymph node. Give the morphologic diagnosis. What type of cells are present?
Chronic pyogranulomatous lymphadenitis Macrophages, fibroblasts, lymphocytes, neutrophils
72
Name the pathologic processes/diseases.
Lymph node hyperplasia - B and T cell expansion * Enlargement and hypercellularlity of cortical follicles, parafollicular areas and medullary cords Metastatic oral squamous cell carcinoma
73
This sample is from an animal with both lymph node hyperplasia and met oral squamous cell carcinoma. Which pathologic process does this area represent?
Lymphoid hyperplasia
74
75
This sample is from an animal with both lymph node hyperplasia and met oral squamous cell carcinoma. Which pathologic process does this area represent?
Met oral SCC
76
Name the organ, pathologic process and etiology
Spleen Splenic nodules/masses - blood-filled Hemangiosarcoma
77
This sample is from a spleen with nodules that were bloody when cut on surface. What is the etiology? What are some features that confirm this diagnosis?
Hemangiosarcoma * Well demarcated mass with blood-filled spaces in the mass – variable in size and lined by epithelial cells * Small caliber vessels in the mass are lined by endothelial cells with high nuclear/cytoplasmic ratios, moderate anisocytosis and anisokaryosis and frequent mitotic figures

Systemic Pathology 2018 (12 decks)

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