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Systemic Pathology 2018 > Lymphoid Images > Flashcards

Lymphoid Images Flashcards

1
Q

What organ is this?

A

Normal thymus

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2
Q

What organ is this?

A

Normal thymus

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3
Q

Name this region of the thymus

A

Cortex

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4
Q

Name this region of the thymus

A

Medulla

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5
Q

Name this structure and region within the thymus. What types of cells is this structure comprised of?

A

Hassall’s corpuscle within the medulla - comprised of thymic epithelial cells that contain coiled layers of keratin

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6
Q

Which region of the thymus is rich in T cells?

A

Medulla

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7
Q

Name this pathologic process and etiology

A

Thymic atrophy due to parvovirus

Other causes: viral, glucocorticoids, nutritional deficiency, toxins

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8
Q

Name this pathologic process and etiology

A

Thymic enlargement = thymoma

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9
Q

This is a histologic image of a thymoma. What is the main cell type?

A

Epithelial cells

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10
Q

What organ is this?

A

Normal spleen

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11
Q

What organ is this? ID the red, purple and pink areas.

A

Spleen

Red = red pulp

Purple = white pulp

Pink = fibrous capsule

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12
Q

What organ is this? ID the purple and red regions. What do these regions supply?

A

Spleen

Red = red pulp = RBC, macrophages (vascular)

Purple = white pulp = B and T cells (lymphoid)

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13
Q

Name the pathologic process and etiology

A

Uniform splenomegaly due to congestion

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14
Q

Name the pathologic process and etiology

A

Uniform splenomegaly due to septicemia

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15
Q

Name the pathologic process and etiology

A

Splenomegaly due to histoplasmosis

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16
Q

Name the pathologic process and morphologic dx?

A

Splenomegaly with chronic diffuse granulomatous splenitis

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17
Q

Name the etiology

A

Hemangioma

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18
Q

Name the pathologic process and etiology

A

Splenic nodule

Hemangioma

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19
Q

Name the pathologic process and etiology

A

Splenic nodule

Hemangiosarcoma

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20
Q

This is from a splenic nodule. What is the likely etiology?

A

Hemangiosarcoma

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21
Q

Name the pathologic process and etiology

A

Splenic nodules/masses

Hemangiosarcoma

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22
Q

Name the pathologic process and etiology

A

Splenic nodule

Splenic infarct with thrombus

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23
Q

Name the pathologic process and etiology

A

Splenic nodular hyperplasia

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24
Q

This is a histopath image from the spleen. Name the etiology.

A

Splenic nodular hyerplasia

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25
Q

Name the pathologic process and etiology

A

Splenic nodules/mass

Splenic metastatic carcinoma

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26
Q

Name the pathologic process and etiology

A

Splenic nodules

Splenic siderotic plaques

Common in old dogs

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27
Q
A

Splenic rupture

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28
Q

What organ is this?

A

Normal lymph node

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29
Q

Name this region of the lymph node. What does it contain?

A

Cortex

Follicles with B cells

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30
Q

Name this region of the lymph node

A

Medulla

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31
Q

Name this region of the lymph node. What is the predominant cell here?

A

Medullary cord

Plasma cells

Increase with immune stimulation

32
Q

Label the areas of the lymph node. What do each of these areas do/contain?

A
  • Capsule = fibrous connective tissue
  • Subcapsular sinus = space that receives afferent lymph
  • Parafollicular zone = densely cellular area between follicles and medulla – contains T cells
  • Medullary sinuses = spaces containing macrophages and small lymphocytes – number of macrophages will increase when inflammation occurs
33
Q

What is this staining for in the lymph node?

A

B cells stain brown – in follicular and medullary cords

T cells stain red – in parafollicular zone

34
Q
A

Lymph node

35
Q
A

Lymph node

36
Q

Name the pathologic process and etiology. What are the causes?

A

Lymphadenomegaly/lymphadenopathy

Lymphadenitis

Causes: infectious, immune, toxic etiology

37
Q

Give the morphologic diagnosis.

A

Acute suppurative and hemorrhagic lymphadenitis

38
Q

Give the morphologic diagnosis.

A

Acute suppurative and hemorrhagic lymphadenitis

Note: lymphotes, necrotic cells

39
Q

Name the pathologic process, etiology and duration

A

Lymphadenomegaly/lymphadenopathy

Lymphadenitis

Chronic (more remodeling)

40
Q

Name the pathologic process, etiology and causes

A

Lymphadenomegaly/lymphadenopathy

Lymphoid hyperplasia

Causes: Ag stimulation, viral infection - Malignant catarrhal fever, BLV, FIV

41
Q

Name the pathologic process, etiology and causes

A

Lymphadenomegaly/lymphadenopathy

Lymphoid hyperplasia

Causes: Ag stimulation, viral infection - Malignant catarrhal fever, BLV, FIV

42
Q

Name the pathologic process and etiology

A

Lymphadenomegaly/lymphadenitis

Lymphoma

43
Q

Name the pathologic process and etiology

A

Lymphadenomegaly/lymphadenitis

Lymphoma

44
Q

Name the pathologic process and etiology

A

Lymphadenomegaly/lymphadenitis

Lymphoma

45
Q

Name the pathologic process and etiology

A

Lymphadenomegaly/lymphadenitis

Multicentric Lymphoma in dogs

46
Q

Name the organ and disease

A

Liver

Lymphoma

47
Q

Name the organ and disease

A

Spleen

Lymphoma with siderotic plaques

48
Q

Name the disease and distribution.

This is the most common form in this species

A

Alimentary lymphoma in cats

49
Q

Name the disease and species

A

Lymphoma in cats

50
Q

Name the disease and species

A

Lymphoma in cats

51
Q

Name the disease and species

A

Lymphoma in cats

52
Q

Name the disease and species

A

Lymphoma in cats

53
Q

Name the disease and species

A

Lymphoma in cats

54
Q

Name the disease and species

A

Lymphoma in cats

55
Q
A
56
Q

Name the disease and species

A

Lymphoma in cats

57
Q

Name the distrubution, disease and species

A

Alimentary lymphoma in cats

58
Q

Name the distrubution, disease and species

A

Alimentary lymphoma in cats

59
Q

Name the disease and species

A

Lymphoma in cattle

60
Q
A
61
Q

Name the distribution, disease and species

A

Multicentric lymphoma in cattle

Abomasum

62
Q

Name the distribution, disease and species

A

Multicentric lymphoma in cattle

Right atrium

63
Q

Name the distribution, disease and species

A

Calf lymphoma in cattle

Bone marrow

64
Q

Name the distribution, disease and species

A

Multicentric lymphoma in cattle

Spinal epidural fat

65
Q

Name the pathologic process and etiology

A

Lymph node atrophy due to canine distemper virus

Note: reduced number of cell density, # of lymphocytes, normal structures not discernable

66
Q

Lymph node atrophy due to distemper virus. What is missing?

A

Medullary cords

67
Q
  • Dog presented with enlarged LN, splenomegaly, neuro signs: collapse, weakness
  • Necropsy: generalized LN enlargement, hepatomegaly, splenomegaly
  • LN were large, off-white on cut surface, loss of cortex and medulla
  • Name the distribution and disease
A

Multicentric lymphoma

68
Q

This is multicentric lymphoma in a dog. What are some notable histological features that confirm this diagnosis?

A
  • Loss of normal architecture
  • Monomorphic medium-sized lymphocytes
  • Lymphocytes extend beyond capsule into perinodal tissue
  • Lymphocytes have coarse, marginated chromatin, prominent nucleoli, mild anisocytosis/anisokaryosis and frequent mitotic figures
69
Q
  • Dog presented with enlarged LN, splenomegaly, neuro signs: collapse, weakness
  • Necropsy: generalized LN enlargement, hepatomegaly, splenomegaly
  • LN were large, off-white on cut surface, loss of cortex and medulla
  • Name the organ, distribution and disease.
  • Which areas are expanded?
A

Multicentric lymphoma

Expanded white pulp areas contain medium sized lymphocytes

70
Q

This is a lymph node. Give the morphologic diagnosis.

A

Chronic pyogranulomatous lymphadenitis

71
Q

This is a lymph node. Give the morphologic diagnosis.

What type of cells are present?

A

Chronic pyogranulomatous lymphadenitis

Macrophages, fibroblasts, lymphocytes, neutrophils

72
Q

Name the pathologic processes/diseases.

A

Lymph node hyperplasia - B and T cell expansion

  • Enlargement and hypercellularlity of cortical follicles, parafollicular areas and medullary cords

Metastatic oral squamous cell carcinoma

73
Q

This sample is from an animal with both lymph node hyperplasia and met oral squamous cell carcinoma. Which pathologic process does this area represent?

A

Lymphoid hyperplasia

74
Q
A
75
Q

This sample is from an animal with both lymph node hyperplasia and met oral squamous cell carcinoma. Which pathologic process does this area represent?

A

Met oral SCC

76
Q

Name the organ, pathologic process and etiology

A

Spleen

Splenic nodules/masses - blood-filled

Hemangiosarcoma

77
Q

This sample is from a spleen with nodules that were bloody when cut on surface. What is the etiology? What are some features that confirm this diagnosis?

A

Hemangiosarcoma

  • Well demarcated mass with blood-filled spaces in the mass – variable in size and lined by epithelial cells
  • Small caliber vessels in the mass are lined by endothelial cells with high nuclear/cytoplasmic ratios, moderate anisocytosis and anisokaryosis and frequent mitotic figures

Systemic Pathology 2018 (12 decks)

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