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MOHDIII - Unit 2 > Lymphoid Disorders > Flashcards

Lymphoid Disorders Flashcards

1
Q

location of B cell maturation

A

bone marrow

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2
Q

Immunophenotype of B cells

A
  • CD19, CD20, CD10
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3
Q

Immunophenotype of T cells

A
  • CD3, CD4, CD5
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4
Q

Location of B & T cells w/ in the spleen

A
  • cortex = B cells

- paracortex = T cells

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5
Q

Reactive lymphadenitis/lymphadenopathies morphology

A
  • follicular (nodular)
  • sinus
  • diffuse
  • granulomatous
  • necrotizing
  • mixed
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6
Q

Reactive lymphoid hyperplasia

A
  • most common in children
  • lymph nodes: tender, soft, freely movable
  • polarized follicles
  • tingible body macrophages, high mitotic activity
  • Bcl-2 NEGATIVE in germinal centers*
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7
Q

Infectious Mononucleosis Lymphadenitis

A
  • induced by EBV
  • primarily effects adolescents
  • REED STERNBERG CELLs
  • positive monospot test, EBV-specific antigens
  • mixed (diffuse/follicular) lymph node pattern
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8
Q

Cat Scratch lymphadenitits

A
  • contact with cats
  • unilateral lymphadenitis
  • necrotizing granulomas w/ PMN cells
  • positive silver stain
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9
Q

Toxoplasma lyphadenitis

A
  • most common parasitic infection in US
  • POSTERIOR CERVICAL lymphadenitis
  • fetal toxoplasmosis as a result of transplacental infection possible
  • IgM>1:80 is diagnostic
  • absence of necrosis
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10
Q

Reactive lymphoid hyperplasia Bcl-2 result

A

RLH the germinal center cells are Bcl-2 NEGATIVE

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11
Q

Children & young adult lymphoid neoplasia

A
  • hodgkin & burkitt lymphomas
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12
Q

Important clinical features of lymphomas

A
  • enlarge, PAINLESS lymphadenopathy

- B symptoms frequent (fever, chills, NIGHT SWEATS)

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13
Q

Lymphoproliferative disorders

A

lymphoma & leukemia

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14
Q

Lymphomas

A

Hodgkin & Non-Hodgkin

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15
Q

Most common lymphomas

A
  • Diffuse large B cell lymphoma: 30.6%

- Follicular lymphoma: 22.1%

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16
Q

Follicular lymphoma

A
  • Adults
  • asymptomatic LN enlargement
  • back to back follicles
  • grade1/2 = 15 centroblasts
  • 2/3 of patients present with > Stage III disease*
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17
Q

Follicular lymphoma: immunophenotype

A
  • CD10 & Bcl-2 postitive

- Bcl 2 gene rearragement: t(14;18)

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18
Q

Follicular lymphoma summary

A
  • adults: 6th decade
  • lymph nodes: firm, mottled, non movable
  • no polarization
  • no tingible body marcrophages, low mitotic activity
  • Bcl 2 positive germinal centers, t(14;18)
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19
Q

Diffuse large B cell lymphoma

A
  • most common type of lymphoma
  • clinically aggresive
  • potentially curable w/ chemo w/ anti CD20(rituximab) & BMT
  • germinal B cell type (GBC) has better prognosis than non GBC type
20
Q

Burkitt lymphoma/leukemia (BL): features and prognosis

A
  • endemic BL: presents as jaw/orbit masses
  • most present with advanced stage
  • curable with aggressive chemo
21
Q

BL - aggressiveness

A

BL very aggressive: dividing time is 24 hours

22
Q

BL immunophenotype

A
  • positive for CD10

- negative for Bcl-2

23
Q

BL cytogenetics

A

typically t(8:14)

24
Q

Mantle cell lymphoma (MCL) - features

A
  • older adults w/ M:F ratio of 3:1

- usually is stage III or IV with extranodal involvement

25
MCL - cytogenetics
- positive for CD5 - t(11:14) - cyclin D1 (Bcl-1)
26
Prognosis of MCL
- despite high tumor response to Tx(80-95%) overall survival is 3-4 yrs - factors: growth pattern, morphology, proliferation index
27
Marginal Zone lymphoma (MZL)
- indolent - associated with Helicobacter pylori infection - Immunophenotype: CD19 & CD20 ONLY****
28
Morphology of MZL
- scattered large cells are always present
29
Hodgkin lymphoma: most common type
Nodular sclerotic classic hodgkins lymphoma
30
Treatment for nodular lymphocyte predominant hodgkins lymphoma
surgery
31
Stats for NSCHL
- prevelance: 70% (of hodgkins lymphomas) - age: 28 - M:F ratio 1:1
32
Clinical features of HL
- responds well to chemo | - CD30, CD15 positive & CD45 negative
33
HL morphology
Reed-Sternberg cell
34
Dianosis of HL
- will not diagnose from FNA
35
HL prevelance
- bimodal age curve showing peak at 15-35 years and second peak after 60 years
36
Chronic lymphocytic leukemia/small lymphocytic leukemia: lymph findings
- diffuse tissue infiltration by small, round neoplastic lympoctyes
37
Transformation of CLL/SLL
- CLL/SLL transformation to DLBCL: RICHTER TRANSFORMATION | - decreased survival: 6-8 months
38
CLL/SLL immunophenotype
- coexpression of CD5, CD23
39
Most common translocations
1. follicular lymphoma: t(14;18) Bcl-2 2. burkitt lymphoma: t(8;14) c-MYC 3. mantle cell lymphoma: t(11;14) cyclin D1
40
CLL/SLL immunophenotype
CD5+, CD20+, CD23+
41
FL immunophenotype
CD10+, CD20+
42
MCL immunophenotype
CD5+, CD20+
43
Burkitt immunophenotype
CD10+, CD20+
44
MZL immunophenotype
CD20+
45
Location of T cell maturation
- thymus | - undergo negative/positive selection

MOHDIII - Unit 2 (23 decks)

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