Bleeding Disorders Flashcards
1
Q
Assessment of intrinsic pathway
A
- partial thromboplastin time (PTT or APTT)
2
Q
Assessment of extrinsic pathway
A
- prothrombin time (PT)
3
Q
How to do prothrombin time
A
- add thromboplastin and calcium to plasma
4
Q
Prothrombin time uses
A
- monitor warfarin (coumadin) therapy
- evaluate liver disease
- evaluate vitamin K deficiency
- evaluate disseminated intravascular coagulation (DIC)
5
Q
International normalized ratio (INR)
A
- uses international sensitivity index (ISI) to normalize PT time
- ISI=measure of the sensitivity of the thromboplastin the lab is using
6
Q
How to do PTT
A
- add activator, calcium, & phospholipid to plasma
7
Q
Reasons for prolonged PTT
A
- heparin
- factor deficiency that may cause bleeding
- factor deficiency w/ no clinical significance (factor XII)
- specific factor inhibitor - most commonly to factor VIII
- antiphospholipid antibody
8
Q
Mixing study
A
- used in evaluation of a prolonged PTT or PT
- patients sample mixed w/ equal volume of normal plasma
- correction to normal = FACTOR deficiency
- continued prolongation = INHIBITOR (aka antibody)
9
Q
Fibrinogen
A
- measured by addition of thrombin to plasma
- may have either quantitative or qualitative abnormalities of fibrinogen
- DECREASED in DIC, liver disease, congenital absence of fibrinogen
10
Q
D-dimer
A
- D-dimer assay detects excess generation of cross linked fibrin by plasmin
- useful in evaluation of DIC
- used in evaluation of venous thrombosis & pulmonary embolism
11
Q
PFA-100 closure times
A
- evaluates platelets
1. col/epi & col/ADP - normal = no platelet abnormality
2. col/epi long & col/ADP normal = aspirin effect
3. col/epi & col/ADP abnormal = platelet defect or von willebrand disease
12
Q
Causes of hemorrhage
A
- trauma, tumor, ulcer, necrosis, depletion of hemostatic factors
13
Q
Petechia
A
- pinpoint hemorrhages in skin
- sign of platelet disorder
14
Q
Purpura
A
- slightly larger hemorrhages than petechia
15
Q
Ecchymoses
A
- large areas of hemorrhage into skin
- aka large bruises
16
Q
Hematoma
A
- localized collection of clotted blood into a space or potential space
17
Q
Platelet
A
- produced in marrow from megakaryocytes
- normal number 150,000-450,000/uL
- remain in circulation 7-10 days
- QUANTITATIVE problems more common than qualitative
- typically causes mucocutaneous bleeding
18
Q
Platelet counts & bleeding risk
A
- minimal bleeding: >50,000
- minor bleeding: 20-50,000
- spontaneous:
19
Q
Thrombocytopenia causes
A
- decreased platelet production
- ineffective platelet production
- splenic sequestration of platelets
- increased peripheral destruction
20
Q
Bone marrow appearance in aplastic anemia
A
- all FAT no cells
21
Q
Increased platelet destruction causes
A
- non immune destruction: DIC, other microangiopathic hemolytic anemias
22
Q
Immune mediated thrombocytopenia
A
- alloimmune destruction: maternal fetal incompatability, blood transfusion
23
Q
Drug induced thrombocytopenia
A
- drug or metabolite attached to platelet surface
- development of antibodies to platelet-drug complex
- platelets removed by macrophages in liver/spleen
- QUININE is prototypic drug
24
Q
Heparin induced thrombocytopeina
A
- caused by antibody directed against heparin & platelet factor 4
- causes platelet AGGREGATION & thrombocytopenia
- may cause life threatening THROMBOSIS