Beta-Blockers Flashcards
1
Q
Nebivolol use
A
- pulmonary HTN
2
Q
Carvedilol use
A
heart failure
3
Q
labetalol use
A
HTN
4
Q
Cardioprotective mechanisms of B-blockers
A
- reduce SNS, balance myocardial O2 supply/demand ratio
- increase threshold for ventricular fibrillation in presence of ischemia
- may increase stability of coronary atherosclerotic plaques
- may reduce myocardial O2 consumption by suppressing lipolysis, causing myocardium to metabolize for glucose instead of FAs
5
Q
Mortality & B-blockers
A
- one of few drugs that have been shown to DECREASE mortality
6
Q
Special effect seen with carvedilol
A
- carvedilol improves insulin sensitivity compared w/ metoprolol and atenolol
7
Q
Very selective B1-blockers
A
- nebivolol
8
Q
SENIORS Trial
A
- nebivolol vs. placebo
- age 70 or older w/ HF: admission for CHF, EF
9
Q
Urgent treatment of tachycardia drug
A
Esmolol
10
Q
tachycardia drug
A
propanolol
11
Q
perioperative SVT drug
A
esmolol
12
Q
Recurrent AF and AFL drug
A
sotalol
13
Q
Ventricular rate control in AF
A
propranolol
14
Q
Dig-induced tachycardia drug
A
propanolol
15
Q
PVC control drug
A
acebutalol, propranolol
16
Q
Life threatening VT
A
sotalol
17
Q
Labetalol
A
- ISA plus alpha blockade
- use: malignant HTN, PHEOCHROMOCYTOMA
18
Q
Verapamil
A
- CCB, liver metabolized
- more potent AV nodal blockade than diltiazem
- drug of choice for multifocal atrial tachycardia, ILVT
- pulmonary friendly
19
Q
Diltiazem
A
- CCB, renal metabolism
- IV & PO forms available
- both verapamil & diltiazem synergistic with beta blockers aka. add a low dose of other class instead of pushing up dose of primary agent*
20
Q
Nadolol
A
- B blocker
- LONG half life: 12-24 hrs
- low lipophilicity
