Lymphedema Flashcards
What is lymph?
Interstitial fluid once it enters the lymph vessels
What are the only organs that do not secrete lymph?
THe brain and spinal cord
What does lymph contain?
protein, water, fatty acids and cellular components of bacteria, viruses and debris
What is the function of lymph?
Keeps connective tissue in a healthy state
Removes fluid, foreign particles from tissues and fats from intestines and returns to bloodstream
Protects body from infection and disease via immune response (lymphocytes)
What are the components of the lymphatic system?
Lymph vessels Lymph nodes Spleen Thymus gland Tonsils Peyers patches Lymphocytes
What are the two segments of a lymph vessel?
The superficial portion (contains Capillaries and pre-collectors-NO VALVES) Deep portion (contains collectors and Trunks. HAVE VALVES)
What are lymphangions?
Valves that separate collectors into functional segments. Resemble veins but have thinner walls and valves in shorter intervals. FROM ONE VALVE TO ONE VALVE.
What does lymphatic fluid flow rely on?
Intrinsic muscle contractions from the smooth muscle within walls of the vessels (lyphangions)
How often do Lymphangions contract at rest? During exercise, heat or inflammation?
6-10x/min. Increases 10 x with exercise, heat or inflammation
What is a lymphotome/watershed?
Distinct, anatomic areas of lymph drainage that drain to regional lymph nodes.
What is lymph drained through to get across a watershed?
Through anastomoses
What are lymph nodes?
Small kidney shaped vessels arranged in chains.
How many lymph node are there in the body? How big are they?
600-700 lymph nodes. About 2-25mm in diameter
Lymphatics vs. Circulation: direction
lymphatics-one way
circulation-circular
Lymphatics vs. Circulation: Amount
lymphatics-1/2 litres/day
circulation-4-8 L/min
Lymphatics vs. Circulation: Contraction
Lymphatic- intrinsic contractions (can also be aided by skeletal muscle contractions)
Circulation-seperate pump (heart)
Lymphatics vs. Circulation: Obstruction
Lymphatics-Obstruction leads to accumulation of high protein fluid (>1.5 gm/dl) doesn’t move well with gravity changes
Circulation-Obstruction leads to collection of low protein fluid (<1gm/dl) moves better with gravity changes
Lymphatics vs. Circulation: Filtering
lymphatics-fluid filtered by lymph nodes
Circulation-no filtering
What is microcirculation?
The 10% of fluid that leaves the arterial end of a capillary that is not reabsorbed by the venous end is reabsorbed by the lymphatic system and returns to circulation.
What are some clinical implications of microcirculation?
- Accumulation of proteins in interstitum w/ impaierd lymphatic system. Will pull water across cell membrane to maintain osmotic equilibrium.
- Loss of elasticity of skin
What is dynamic insufficiency?
Healthy lymphatic system but LL exceeds TC
Happens during sprained ankle, DVT, cardiac edema
What is mechanical insufficiency?
Diseased lymphatic system, normal LL exceeds impaired TC
Lymph node removal
What is lymphedema?
Abnormal accumulation of protein-rich fluid in the interstitial that occurs when the lymph load exceeds the lymph transport capacity (general but heavily debated)
What are the signs and symptoms of lymphedema?
slow, progressive onset
pt feels limb is heavy, not painful
usually starts distally and is asymmetrical
What is Primary lymphedema?
Hereditary or congenetial
What is secondary lymphedema?
Acquired
Result of damage to soft tissue, lymph vessels or nodes
secondary to radiation, surgery, tumor infection
mosquito bite (Filariasis)
What are the 4 stages of lymphedema?
Sub-clinical stage 0-feeling of heaviness in limb w/o any visible swelling
Stage 1- pits on pressure, high water content, reduces with elevation, reversible
Stage 2-Non-pitting, not reduced by elevation, moderate to severe clinical fibrosis
Stage 3-Elephantiasis-skin changes, lobules
Who experiences primary lymphedema most?
females 87%