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RUSVM Immunology > Lymphcyte Receptors > Flashcards

Lymphcyte Receptors Flashcards

1
Q

What are the sub populations of lymphocytes?

A 
NK cells (innate) 
T cells (cellular)
B cells (humoral)
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2
Q

What is the primary lymphoid tissue of T cells?

A

Thymus

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3
Q

What is the primary lymphoid tissue of B cells?

A

Bone marrow/ bursa of fabricius

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4
Q

Where are T cells found in secondary lymphoid tissues?

A

Paracortex lymph nodes
Periarteriolar lymphoid sheets of spleen
Interfollicular area of payer patch
Blood

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5
Q

Where are B cells found in secondary lymphoid tissue?

A

Follicles in peyers patch
Cortex in lymph nodes
Marginal zone in white pulp of the spleen
Blood

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6
Q

What are the two types of Tcell antigen-binding chain??

A

TCR a/B

TCR y/delta

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7
Q

What is the receptor for MHC II and what T cells are they found on?

A

CD4

Helper T cells

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8
Q

What is the receptor for MHC I and what Tcells are they present on?

A

CD8

Cytotoxic T cells

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9
Q

What are the three selectins in vascular endothelial cells?

A

P selectin
L selectin
E selectin

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10
Q

What type of antigens to Bcells recognize?

A

Free foreign proteins

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11
Q

What antigens are recognized by Tcell receptors?

A

Processed antigen that is presented on MHC

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12
Q

B cells secrete what products?

A

Antibodies

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13
Q

Tcells secrete what products?

A

Cytokines

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14
Q

What are the 5 types of Bcell receptor antigen binding chains?

A 
BCR a
BCR y
BCR u 
BCR E
BCR delta
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15
Q

Antibody vs BCR?

A

Antibodies are soluble BCR (BCR bound to B cell membrane)

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16
Q

Activation of T cells has what two main effects?

A

Division/proliferation to memory and effector T cells

Cytokines production

17
Q

Activation of B cells what two main effects?

A

Production of antibodies

Differentiation to plasma and memory Bcells

18
Q

What receptors are important for the activation and migration of lymphocytes into tissues?

A

Integrins and selectins

19
Q

What are the four populations of cells with antigen binding receptors?

A

Helper Tcells
Cytotoxic Tcells
Regulatory Tcells
Bcells

20
Q

Endogenous or exogenous antigens are presented by dendritic cells by ________ to _____________

A

MHC

Helper Tcells

21
Q

Helper Tcells 1 (Th1) are associated with what immune response?

A

Cellular (cytotoxic ) response

22
Q

Helper Tcells 2 (Th2) are associated with what immune response?

A

Humoral (Bcell)

23
Q

What are the features of the lymphocyte receptor immunoglobulin superfamily?

A

Variable, constant, transmembrane, and cytoplasmic regions

Antigen binding groove (hypervariable sequence)

24
Q

What receptors belong to the Ig superfamily?

A

TCR(a/B and y/delta)
MHC (I and II)
BCR

25
Q

The CD3 complex structure and function?

A

5 protein chains, arranged in dimers

Signal transduction

26
Q

What accessory molecules are found on Tcells and what do they bind?

A

CD4 -> MHC II (helper Tcell)

CD8 -> MHC I (cytotoxic Tcell)

27
Q

What is the sequence of co-stimulatory signals following TCR binding to antigen on MHC?

A

CD3 transmits signal to CD40 (Tcell) bound to CD154 (APC) causing pro-inflammatory cytokine production

CD28 (Tcell) bound to CD80(APC)/86(Bcell) causes upregulation of survival genes, increased metabolism, and division

CD152 (Tcell) bound to CD80(APC)/86(Bcell) causes Tcell suppression by production of indolamine dioxygenase which destroys tryptophan

Sequence of events leading to activation followed by inactivation

28
Q

The __________ domain of the TCR is explicit for binding a specific antigen

A

Variable

29
Q

Tcell binding to a processed antigen activates the immune response by ?

A

Cytokines production
Mitosis
Cell differentiation

30
Q

CD3 is found in all Tcells and its main role is _______________________

A

Signal transduction

31
Q

Co-stimulatory signals are important in development of helper Tcell types. High IL12 leads to Th ____, no IL12 leads to Th____, IL23 leads to Th___ development .

A

High IL12 = Th1
No IL12 = Th2
IL23 = Th 17

RUSVM Immunology (10 decks)

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