Lymphcyte Receptors Flashcards
What are the sub populations of lymphocytes?
NK cells (innate) T cells (cellular) B cells (humoral)
What is the primary lymphoid tissue of T cells?
Thymus
What is the primary lymphoid tissue of B cells?
Bone marrow/ bursa of fabricius
Where are T cells found in secondary lymphoid tissues?
Paracortex lymph nodes
Periarteriolar lymphoid sheets of spleen
Interfollicular area of payer patch
Blood
Where are B cells found in secondary lymphoid tissue?
Follicles in peyers patch
Cortex in lymph nodes
Marginal zone in white pulp of the spleen
Blood
What are the two types of Tcell antigen-binding chain??
TCR a/B
TCR y/delta
What is the receptor for MHC II and what T cells are they found on?
CD4
Helper T cells
What is the receptor for MHC I and what Tcells are they present on?
CD8
Cytotoxic T cells
What are the three selectins in vascular endothelial cells?
P selectin
L selectin
E selectin
What type of antigens to Bcells recognize?
Free foreign proteins
What antigens are recognized by Tcell receptors?
Processed antigen that is presented on MHC
B cells secrete what products?
Antibodies
Tcells secrete what products?
Cytokines
What are the 5 types of Bcell receptor antigen binding chains?
BCR a BCR y BCR u BCR E BCR delta
Antibody vs BCR?
Antibodies are soluble BCR (BCR bound to B cell membrane)
Activation of T cells has what two main effects?
Division/proliferation to memory and effector T cells
Cytokines production
Activation of B cells what two main effects?
Production of antibodies
Differentiation to plasma and memory Bcells
What receptors are important for the activation and migration of lymphocytes into tissues?
Integrins and selectins
What are the four populations of cells with antigen binding receptors?
Helper Tcells
Cytotoxic Tcells
Regulatory Tcells
Bcells
Endogenous or exogenous antigens are presented by dendritic cells by ________ to _____________
MHC
Helper Tcells
Helper Tcells 1 (Th1) are associated with what immune response?
Cellular (cytotoxic ) response
Helper Tcells 2 (Th2) are associated with what immune response?
Humoral (Bcell)
What are the features of the lymphocyte receptor immunoglobulin superfamily?
Variable, constant, transmembrane, and cytoplasmic regions
Antigen binding groove (hypervariable sequence)
What receptors belong to the Ig superfamily?
TCR(a/B and y/delta)
MHC (I and II)
BCR
The CD3 complex structure and function?
5 protein chains, arranged in dimers
Signal transduction
What accessory molecules are found on Tcells and what do they bind?
CD4 -> MHC II (helper Tcell)
CD8 -> MHC I (cytotoxic Tcell)
What is the sequence of co-stimulatory signals following TCR binding to antigen on MHC?
CD3 transmits signal to CD40 (Tcell) bound to CD154 (APC) causing pro-inflammatory cytokine production
CD28 (Tcell) bound to CD80(APC)/86(Bcell) causes upregulation of survival genes, increased metabolism, and division
CD152 (Tcell) bound to CD80(APC)/86(Bcell) causes Tcell suppression by production of indolamine dioxygenase which destroys tryptophan
Sequence of events leading to activation followed by inactivation
The __________ domain of the TCR is explicit for binding a specific antigen
Variable
Tcell binding to a processed antigen activates the immune response by ?
Cytokines production
Mitosis
Cell differentiation
CD3 is found in all Tcells and its main role is _______________________
Signal transduction
Co-stimulatory signals are important in development of helper Tcell types. High IL12 leads to Th ____, no IL12 leads to Th____, IL23 leads to Th___ development .
High IL12 = Th1
No IL12 = Th2
IL23 = Th 17
