Lymphcyte Receptors

Question 1

What are the sub populations of lymphocytes?

Answer 1

NK cells (innate) 
T cells (cellular)
B cells (humoral)

Question 2

What is the primary lymphoid tissue of T cells?

Answer 2

Thymus

Question 3

What is the primary lymphoid tissue of B cells?

Answer 3

Bone marrow/ bursa of fabricius

Question 4

Where are T cells found in secondary lymphoid tissues?

Answer 4

Paracortex lymph nodes
Periarteriolar lymphoid sheets of spleen
Interfollicular area of payer patch
Blood

Question 5

Where are B cells found in secondary lymphoid tissue?

Answer 5

Follicles in peyers patch
Cortex in lymph nodes
Marginal zone in white pulp of the spleen
Blood

Question 6

What are the two types of Tcell antigen-binding chain??

Answer 6

TCR a/B

TCR y/delta

Question 7

What is the receptor for MHC II and what T cells are they found on?

Answer 7

CD4

Helper T cells

Question 8

What is the receptor for MHC I and what Tcells are they present on?

Answer 8

CD8

Cytotoxic T cells

Question 9

What are the three selectins in vascular endothelial cells?

Answer 9

P selectin
L selectin
E selectin

Question 10

What type of antigens to Bcells recognize?

Answer 10

Free foreign proteins

Question 11

What antigens are recognized by Tcell receptors?

Answer 11

Processed antigen that is presented on MHC

Question 12

B cells secrete what products?

Answer 12

Antibodies

Question 13

Tcells secrete what products?

Answer 13

Cytokines

Question 14

What are the 5 types of Bcell receptor antigen binding chains?

Answer 14

BCR a
BCR y
BCR u 
BCR E
BCR delta

Question 15

Antibody vs BCR?

Answer 15

Antibodies are soluble BCR (BCR bound to B cell membrane)

Question 16

Activation of T cells has what two main effects?

Answer 16

Division/proliferation to memory and effector T cells

Cytokines production

Question 17

Activation of B cells what two main effects?

Answer 17

Production of antibodies

Differentiation to plasma and memory Bcells

Question 18

What receptors are important for the activation and migration of lymphocytes into tissues?

Answer 18

Integrins and selectins

Question 19

What are the four populations of cells with antigen binding receptors?

Answer 19

Helper Tcells
Cytotoxic Tcells
Regulatory Tcells
Bcells

Question 20

Endogenous or exogenous antigens are presented by dendritic cells by ________ to _____________

Answer 20

MHC

Helper Tcells

Question 21

Helper Tcells 1 (Th1) are associated with what immune response?

Answer 21

Cellular (cytotoxic ) response

Question 22

Helper Tcells 2 (Th2) are associated with what immune response?

Answer 22

Humoral (Bcell)

Question 23

What are the features of the lymphocyte receptor immunoglobulin superfamily?

Answer 23

Variable, constant, transmembrane, and cytoplasmic regions

Antigen binding groove (hypervariable sequence)

Question 24

What receptors belong to the Ig superfamily?

Answer 24

TCR(a/B and y/delta)
MHC (I and II)
BCR

Question 25

The CD3 complex structure and function?

Answer 25

5 protein chains, arranged in dimers Signal transduction

Question 26

What accessory molecules are found on Tcells and what do they bind?

Answer 26

CD4 -> MHC II (helper Tcell) | CD8 -> MHC I (cytotoxic Tcell)

Question 27

What is the sequence of co-stimulatory signals following TCR binding to antigen on MHC?

Answer 27

CD3 transmits signal to CD40 (Tcell) bound to CD154 (APC) causing pro-inflammatory cytokine production CD28 (Tcell) bound to CD80(APC)/86(Bcell) causes upregulation of survival genes, increased metabolism, and division CD152 (Tcell) bound to CD80(APC)/86(Bcell) causes Tcell suppression by production of indolamine dioxygenase which destroys tryptophan Sequence of events leading to activation followed by inactivation

Question 28

The __________ domain of the TCR is explicit for binding a specific antigen

Answer 28

Variable

Question 29

Tcell binding to a processed antigen activates the immune response by ?

Answer 29

Cytokines production Mitosis Cell differentiation

Question 30

CD3 is found in all Tcells and its main role is _______________________

Answer 30

Signal transduction

Question 31

Co-stimulatory signals are important in development of helper Tcell types. High IL12 leads to Th ____, no IL12 leads to Th____, IL23 leads to Th___ development .

Answer 31

High IL12 = Th1 No IL12 = Th2 IL23 = Th 17