Lymphatic System - Module 11 Flashcards
Lymphatic System
This system detects and inactivates foreign substances
Lymphatic System/Lymphoid Sy
stem
Formed when interstitial fluid seeps into lymphatic vessels
Lymphatic Fluid
Lymph fluid draining the gut which is milky and contains a lot of triglycerides
Chyle
The stroma of all lymphoid organs except thymus is composed of what tissue
Reticulin Fibers
Stroma of Thymus is composed of what tissue
Epithelial Reticular Cells
This is the term for substances that are stainable with silver stains
Argyrophylic
Cells of the Lymphoid System
B-Lymphocytes, T-Lymphocytes, Natural Killer Cells
Technique used to look for markers (Molecules) on the surface of the cells
Flow Cytometry
What are the anti-gen presenting Cells
Macrophage, Dendritic Cells
Two types of immunity
Cell Immunity and Humoral Immunity
This immunity is acquired when B cells turn into plasma cells that makes anti-bodies that coats and eliminates microorganisms
Humoral Immunity
This immunity is acquired when T cells turn to cytotoxic cells and Helper T cells
Cellular Immunity
Primary Maturation sites of Lymphocytes
Bone Marrow, Thymus, Bursa of Fabricius in avians
Where B lymphocytes arise and mature
Bone Marrow
Where T Lymphocytes mature
Thymus
Located in the Mediastinum; Lobulated and capsulated structure
Thymus
2 Lobules of the Thymus
Cortex and Medulla
Term for cells in the Thymus
Thymocyte(s) and Thymic Epithelial Reticular Cells
True or False, T cells in medulla are immature
False, they’re mature
True or False, T cells in cortex are undergoing various stages of differentiation
True
So much T cells are produced, but how much of them dies (in percentage)
97%, only 3% lives
Are made up of degenerating epithelial reticular cells and keratin filaments. Unknown Function
Hassll’s Corpuscle
True or False, Thymus is heaviest at puberty
True
True or False, The Thymus completely disappears after puberty
False, it involutes but never disappears completely
What are the Secondary Lymphoid Organs
Lymph Nodes, Spleen, Mucosa-associated Lymphoid Tissue (MALT)
Lymph Node Architecture
Outer Cortex, Paracortex, Medulla
This structure of lymph node contains round structure called Lymphoid follicles which are composed of B-Cells
Outer Cortex
This structure of lymph node contains T cells and High Endothelial Venules
Paracortex
This structure of lymph node is composed of cords and sinuses
Medulla
Lymph Node follicles made up of small, dark, and mature Lymphocytes
Primary Unstimulated Follicles
Lymph Node Follicle made up of Germinal Center and Mantle Zone
Secondary Stimulated Follicles
The lymph node capsule and trabeculae consists of what tissue
Dense Irregular Connective Tissue
This lymphatic vessel penetrates the capsule of lymph node on convex sides and carry lymph from site of infection back to the lymph nodes
Afferent Lymphatic Vessels
This Lymphatic Vessel leaves through the hilum carry lymph from lymph node and returns it to the blood
Efferent Lymphatic Vessels
Is the depression in the concave surface of a lymph node
Hilum/Hilus
How does Lymph flow through the node
Afferent Lymphatic > Subscapular Sinus > Intermediate Sinus > Medullary Sinus > Efferent Lymphatics > Larger Lymphatics > Blood
Located in Paracortex that allows lymphocytes in blood vessels to adhere to endothelial cells and migrate across vessel wall to the lymphoid tissue
High Endothelial Venules
Lymphocytes move from blood circulation to lymphatic circulation via ________________
High Endothelial Venules
How do lymphocytes get from blood to lymph
Hilar Arterioles > Arterioles > Capillaries > High-endothelial venules > Lymphocyte enter lymphatic circulation > Efferent Lymph Vessels
Functions of Spleen
Immunologic Blood Filtration, Proliferation of Lymphocytes, Removal of Old RBC
True or False, Spleen has no cortex and medulla
True
The parenchyma of spleen is called __________ and has white and red pulp
Splenic Pulp
What are the stroma of spleen
Capsule, Trabeculae, Reticular Connective Tissue
White Pulp of Spleen consists of ____________ and ______________
Splenic Follicles and Periateriolar Lymphatic Sheaths
These are circular collections of T cells around arterioles in the White Pulp
Periarteriolar Lymphatic Sheaths (PALS)
These are similar to secondary follicles in lymph nodes but with one more layer (Marginal Zone)
Splenic Follicles
This red pulp of the spleen is lined with specialized endothelial cells (Stave Cells) surrounded by rings of reticular fibers in which healthy red cells can easily pass through
Splenic Sinuses (Sinusoids)
This red pulp of the spleen is located between the sinuses containing red cells, granulocytes, lymphocytes, macrophages, platelets, and plasma cells
Splenic Cords (Cords of Billroth)
This are specialized endothelial cells in Splenic Sinuses
Stave Cells
Meaning of MALT
Mucosa Associated Lymphoid Tissue
What type of Lymphoid Tissue lines the mucosa and submucosa of Digestive, Respiratory, Reproductive, and Urinary System
Mucosa Associated Lymphoid Tissue (MALT)
What are the three types of tonsils
Pharyngeal, Palatine, Lingual
This tonsil is located at the midline of nasopharynx with gentle folds on its surface
Pharyngeal Tonsil
These are 2 tonsils in lateral Oropharynx lined with Stratified Squamous Epithelium
Palatine Tonsils
This Tonsil has numerous small tonsils at base of tongue and is lined with stratified squamous epithelium
Lingual Tonsil
True or False, Each Lingual tonsil is capsulated
False, it has no capsule
True or False, Pharyngeal Tonsil is lined with stratified columnar epithelium
False, Pseudostratified Ciliated Columnar Epithelium