Lucas part 7 Flashcards

1
Q

Structure of smoot muscle:

____, ____-shaped cells compared to skeletal muscle.
____ nucleus per cell. (single or multiple)
____ striations because thick and thin filaments are not organized into sarcomeres.

A

small, spindle, single, lacks

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2
Q

Key Differences from Skeletal Muscle:
1) No ____, ____, or ____.
2) Thick filaments lack a “____” allowing more flexibility in filament interactions.

A

T-tubules, DHPRs, or RyRs
bare zone

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3
Q

function of smooth muscle

A

Controls involuntary movements such as peristalsis, blood flow regulation, and bladder emptying.

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4
Q

where is smooth muscle found

A

blood vessels, digestive tract, bladder, uterus, and respiratory tract.

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5
Q

Thin and thick filaments are arranged in a ____ network rather than sarcomeres.
During contraction, thin filaments slide past thick filaments in ____ directions, shortening the cell.

A

lattice-like, opposite

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6
Q

Change of Partners During Stretch:

A

During stretch, myosin heads move to interact with new thin filaments. So original filaments sets no longer overlap

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7
Q

Stress-Relaxation Property:

A

Initial force from stretch decreases over time as filaments reorganize.

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8
Q

what is the purpose of the stress-relaxation property

A

accommodating changes in organ size, such as in the bladder or stomach.

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9
Q

Single-Unit Smooth Muscle:

Features:
Connected by ____, allowing cells to contract as a ____ unit.
____ (self-excitable).
Examples: ____, ____.

A

gap junctions, single myogenic, guts, bladder

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10
Q

Multi-Unit Smooth Muscle:
Features:
Each cell acts ____, requiring ____.
____ (controlled by nerves).
Examples: ____, iris of the eye, ____ follicles.

A

independently, direct neural stimulation
neurogenic

blood vessels, hair follicles

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11
Q

Phasic vs. Tonic Contractions:

Phasic:
____, ____ contractions (e.g., ____ in the intestines).

Tonic:
____ contractions (e.g., maintaining ____ tone).

A

rhytmic, intermitten, perilstasis

sustained, blood vessel

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12
Q

Myogenic Excitation

2 types of potentials:

A

Pacemaker Potentials and Slow Wave Potentials

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13
Q

Pacemaker Potentials:
____, ____ changes in membrane potential.
Trigger ____ and contractions.

A

spontaneous, rhytmic, action potentials

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14
Q

Slow Wave Potentials:
____ fluctuations in membrane potential, requiring ____ (e.g., ____ signals) to reach the action potential threshold.

A

gradual, ANS signals, additional input

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15
Q

Neurogenic Excitation
____:
Swellings along ____ nerve fibers release ____.
Neurotransmitters ____ across the smooth muscle, stimulating contraction.

A

varicosities, autonomic, neurotransmitters, diffuse

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16
Q

Smooth muscle relies on ____ for contraction. Calcium can enter the cell via: (3 ways)

A

cytoplasmic contraction

Voltage-Gated Ca²⁺ Channels:

Second-Messenger Pathways:

Store-Operated Ca²⁺ Channels:

17
Q

Voltage-Gated Ca²⁺ Channels:
Opened by ____.

A

action potentials

18
Q

Second-Messenger Pathways:
____ trigger the release of calcium from the ____

A

GPCRs, SR

19
Q

Store-Operated Ca²⁺ Channels:
Open in response to depletion of ____.

A

SR calcium stores

20
Q

What is found on myosin heads and control ATPase activity

A

myosin light chains

21
Q

mechanism for smooth muscl filament contraction

Ca²⁺ binds to ____.
The Ca²⁺-CaM complex activates ____
MLCK phosphorylates ____, activating ____.
ATPase hydrolyzes ATP, powering the cross-bridge cycle and contraction.

A

CaM (Calmodulin), MLCK (MLC kinase), MLC, myosin atpase

22
Q

Relaxation Process for smooth muscle
Process:

____ is pumped out of the cytoplasm, reducing cytosolic levels.
Low Ca²⁺ deactivates ____.
____ dephosphorylates ____, stopping the ATPase activity.
The cross-bridge cycle halts, and the muscle relaxes.

A

Calcium, MLCK, MLC phosphotase, MLC

23
Q

Smooth Thin Filament Regulation

____:
Blocks myosin-binding sites on g actin in the absence of ____⁺.

Ca²⁺-CaM Complex:
Removes ____, exposing actin and enabling cross-bridge formation.

A

caldesmon, calcium, caldesmon

24
Q

3 factors that promoting contraction:

A

para and sympathetic ANS (acth, epinephrine, norepinephrine)
serotonin
stretch
alpha 1 receptors

25
Q

3 factors that promote relaxation

A

sympathetic ANS (nor + epi)
beta 2 receptors
inhibit mlck
hormones from blood

26
Q

is there a length-tension curve in smooth muscle

A

no

27
Q

During pregnancy, uterine smooth muscle transitions from ____-unit to ____-unit to enable coordinated contractions for childbirth.

A

multi to single

28
Q

the hyperpolarization in pacemaker potentials is from

A

leaky ion channels

29
Q

the hyperpolarization in slow wave potentials is in

A

random bursts

30
Q

the increase AP in pacemaker potentials is from

A

calcium

31
Q

the increase in AP in slow wave potentials is from

A

bursts