LTP + LTD Flashcards
What is a hebbian synapse?
Coordinated activity of a presynaptic terminal and a postsynaptic neuron strengthen the synaptic connections between them
What is spatial memory?
Form of memory responsible for recording information about one’s environment and spatial orientation
What type of memory does the hippocampus store?
Spatial
What is the hippocampal circuit?
Dentate gyrus CA3 CA1 fornix and subiculum
Where do LTPs happen?
CA3 CA1
What does a high frequency stimulation cause?
Long-term potentiation (LTP)
What are schaffer collaterals?
The processes sent to the CA1 cells by the CA3 cells
What is cooperativity in LTP?
LTP can be induced either by strong tetanic stimulation of a single pathway to a synapse, or cooperatively via the weaker stimulation of many. When one pathway into a synapse is stimulated weakly
What blocks NMDA receptors?
Mg2+
How are they then activated? (NMDA)
By a separate depolarising input
What are the 2 types of LTP?
Early and late
What causes early phase? (LTP)
NMDA mediated Ca influx activates calmodulin kinase – delivery of more AMPA receptors
What does late LTP need?
Protein synthesis
What is LTD?
Long term depression – long lasting reduction in synaptic efficiency
What are the 2 types of LTD?
Depotentiation – removal of previous potentiation
New – no previous potentiation
