Faulty neural circuits

Question 1

What kind of stimulation do you need? LTD

Answer 1

Low frequency (1-5Hz)

Question 2

What does LTD activate?

Answer 2

Low amounts of protein phosphatases which are activated by low amount of CA

Question 3

What do protein phosphatases do?

Answer 3

Take away the phosphorylation of the AMPA receptors and lead to synaptic depression

Question 4

Does LTP and LTD = memory?

Answer 4

No - monkeys in enriched environments have more dendrites

Question 5

What is halorhodopsin activated by?

Answer 5

yellow light

Question 6

What does halorhodopsin do to the membrane?

Answer 6

Hyperpolarise

Question 7

What does channelrhodopsin do?

Answer 7

depolarise

Question 8

what can you use instead of channelrhodopsin?

Answer 8

Small organic molecules

Question 9

What can light induce in these small molecules (Small organic molecules)

Answer 9

Cis-trans isomerisation

Question 10

What isomer blocks channel?

Answer 10

Trans-isomer blocks whilst cis-isomer unblocks

Question 11

Which isomer has a bigger current?

Answer 11

Cis isomer

Question 12

What is GABA important for?

Answer 12

Regulating excitable activity

Question 13

What is retina pigmentosa and what is it caused by?

Answer 13

Gradual loss of vision peripheral ==> centre due to the breakdown of the retina