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farmaco > lp 7 > Flashcards

lp 7 Flashcards

1
Q

tipuri de efecte glucocorticoizi

A
  • metabolice
  • farmacodinamice- pt efectele astea se fol de obicei ca medicamente
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2
Q

efecte metabolice glucocorticoizi

A

influenteaza metabolismele:
* glucidic
* lipidic
* protidic
* hidromineral

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3
Q

cum influenteaza glucocorticoizii metab glucidic

A
  • intensificare gluconeogeneza hepatica
  • crestere depozite hepatice glicogen
  • scade utilizare cel glucoza
  • creste glicemia
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4
Q

cum influenteaza glucocorticoizii metabolismul lipidic

A
  • lipoliza
  • creste secretia de insulina=> lipogeneza
  • redistribuire tesut adipos- aparitie facies in luna plina, ceafa bizon
  • depunere tes adipos abdomen
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5
Q

cum influenteaza glucocorticoizii metabolismul protidic

A
  • catabolism proteic
  • inhibare sinteza proteine
  • diminuare procese crestere
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6
Q

unde se produce catabolism proteic provocat de glucocorticoizi

A
  • oase- resorbtie matrice osoasa, crestere elim urin Ca, OSTEOPOROZA
  • muschi scheletici- miopatie cortizonica
  • piele- vergeturi, fenomene atrofice, telangiectazii
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7
Q

cum influenteaza glucocorticoizii metabolismul hidromineral

A
  • retentie sodiu si apa
  • pierdere de potasiu
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8
Q

influenta anumitor medicamente pe metab hidromineral

A
  • glucocortic naturali- retentie hidrosalina mare
  • prednison+ metilprednison- medie
  • dexametazona- nu are efect mineralocorticoid
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9
Q

cand se folosesc glucocorticoizii pentru efectele metabolice

A

insuficienta corticosuprarenala- boala Addison

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10
Q

efecte farmacodinamice glucocorticoizi

A
  • antiinflamator
  • antialergic
  • limfolitic
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11
Q

efect antiinflamator glucocorticoizi

A
  • intens
  • influenteaza toate fazele inflamatiei- congestiva, exudativa, necrotica, proliferativa
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12
Q

efect antialergic glucocorticoizi

A
  • rezulta din actiune imunodepresiva+ antiinflam
  • deprima imunitatea imediata
  • pot scadea productia de anticorpi
  • inhiba reactii anafilactice
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13
Q

efect limfolitic glucocorticoizi

A
  • limfopenie trecatoare
  • utilizat pt boli hematologice
  • scade eozinofile
  • creste leucocite
  • creste hemoglobina, nr hematii
  • creste trombocite
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14
Q

indicatii terapeutice glucocorticoizi

A
  • boli inflamatorii
  • boli autoimune
  • boli alergice severe
  • boli hematologice
  • insuficienta corticosuprarenala- tratament substitutie
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15
Q

reactii adverse importante la glucocorticoizi

A
  • hipercorticism exogen
  • hipocorticism endogen
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16
Q

hipercorticism exogen
* cand apare
* aspect pacient

A

-dupa tratament indelungat doze medii/ mari- aprox 2 sapt
aspect boala Cushing

17
Q

hipocorticism endogen

A

insuf corticosuprarenala cauzata de inhibarea acesteia si atrofierea progresiva

18
Q

cand devine evidenta insuficienta corticosuprarenala cauzata de glucocorticoizi

A
  • in conditii de stres
  • oprire brusca adm medicament
19
Q

masuri prevenire hipocorticism endogen si corticodependenta

A
  • adm medicament dimineata/ doza dubla o data la 2 zile(pt doze mici/ medii)
  • intrerupere tratament lenta
  • tratam justificat cu doze minime eficace
20
Q

principalii glucocorticoizi naturali

A
  • hidrocortizon
  • cortizon
21
Q

adm hidrocortizon

A
  • hemisuccinat- IV, in urgente
  • acetat- adm local, rar
  • cpr- insuf corticosuprarenala
22
Q

glucocorticoizi de sinteza

A
  • prednison
  • prednisolon
  • metilprednisolon
  • triamcinolona
  • dexametazona
  • betametazona
22
Q

adm cortizon

A

rar ca medicatie de substitutie in insuf corticosuprarenala

23
Q

diprophos

A

suspensie injectabila:
* intraarticular- ATM
* periarticular
* intralezional
* IM- preparat de depozit

24
Q

glucocorticoizi adm pe tegumente

A
  • Mometasona furoat- Elocom
  • Metilprednisolon aceptonat (Advantan)
  • Fluocinolon acetonid
  • Clobetasol ( Dermovate)
25
Q

glucocorticoizi care se administreaza numai inhalator

A
  • Fluticazona
  • Budesonida
  • Mometazona (Asmanex)
26
Q
A

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