lp 6

Question 1

doze in care se poate asocia adrenalina pt anestezice locale

Answer 1

1/ 50.000-1/ 200.000

Question 2

date despre lidocaina

Answer 2

• anestezic local
• durata medie de actiune
• potenta medie
• act prin inhibare propagare impuls nervs ca urmare a scadere permeab mb la ioni Na

Question 3

date despre adrenalina in combinatie cu lidocaina

Answer 3

• reduce efect vasodilatator lidoc
• creste intensitate si durata anestezie
• scade risc sangerare
• scade toxicitate lidoc

Question 4

lidocaina utilizata singura ca anestezie

Answer 4

=xilina
* solutie 1%- fiole de 10ml si 20 ml
* solutie 2%- fiole de 2ml
* solutie 4%- fiole de 2 ml

Question 5

principalii alcaloizi din opiu

Answer 5

• codeina
• morfina

Question 6

compusi sintetici inruditi cu morfina

Answer 6

• fentanyl
• tramadol
• metadona
• petidina ( mialgin)

Question 7

tip formular prescriere morfina

Answer 7

galben

Question 8

forme farmaceutice morfina

Answer 8

• fiole- morfina clorhidrica/ sulfurica - 1 fiola=20 mg mrofina
• cpr obisnuite- Sevredol
• cpr retard- Vendal
• preparate de opiu-tinctura opiu (1% morfina) si pulbere opiu( 10%)

Question 9

mecanism actiune morfina

Answer 9

agonist pe receptori opioizi- receptori endorfinici
ii stimuleaza

Question 10

efecte morfina

Answer 10

• analgezic
• sedativ
• anxiolitic intens

Question 11

dureri acute intense care necesita morfina

Answer 11

• dureri postop
• dureri fracturi
• durere infarct acut miocard
• durere colica renala- preferabil asociat cu ATROPINA care contracareaza efect spastic morfina pe musc netd

Question 12

ce forme de morfina se utilizeaza in durere cronica( neoplazii)

Answer 12

Sevredol- cpr cu elib imediata
Vendal- cpr retard
*uneori pompe automate de perfuzie

Question 13

efecte codeina

Answer 13

analgezic
antitusiv

Question 14

doze adm codeina ca analgezic

Answer 14

• singura: pana la 30-50 mg o data
• asociata cu Paracetamol, Ibuprofen, Aspirina: 10-30 mg o data

Question 15

pe ce se prescrie codeina

Answer 15

formular verde

Question 16

de ce nu se administreaza morfina in durere reumatica

Answer 16

raspuns la morfina slab

Question 17

utilizare fentanyl

Answer 17

• anestezic injectabil iv
• analgezie in dureri neoplazice

Question 18

forme fentanyl utilizate ca analgezice pt dureri neoplazice

Answer 18

• plasturi- se schimba la 3 zile
• cpr pt supt- sublingual la nev

Question 19

cum se adm tramadol

Answer 19

adm orala/ inj
dureri intensitate medie
-risc dependenta mic

Question 20

forme tramadol

Answer 20

• cps
• cpr retard
• fiole

Question 21

preparate care asociaza tramadol cu paracetamol

Answer 21

• Doreta
• Zaldiar

Question 22

variante doreta

Answer 22

• cpr 37,5/ 325 mg
• cpr 75/650mg

Question 23

variante zaldiar

Answer 23

37,5/325 mg

Question 24

preparate care asociaza codeina cu un analegzic non opioid

Answer 24

• Codamin P
• Nurofen Plus 200/12,8 mg

Question 25

cum se mai numesc analgezicele antipiretice antiinflamatoare nesteroidiene

Answer 25

pe scurt- antiinflamatoare nesteroidiene (AINS)

Question 26

mecanism actiune AINS

Answer 26

INHIBARE CICLOOXIGENAZA
=>scadere sinteza prostaglandine+ tromboxan

Question 27

cum se explica efect antiinflamator si analgezic AINS

Answer 27

scadere sinteza PG tesut afectat
*posibil contribuie si inhibare COX nivel central

Question 28

cum se explica efect antipiretic AINS

Answer 28

urmare a inhibare sinteza de prostaglandine hipotalamus (m ales PGE2)

Question 29

forme ciclooxigenaza

Answer 29

• COX 1= enzima constitutiva
• COX 2= enzima inductibila

sunt izoforme

Question 30

actiune COX1

Answer 30

determina sinteza de prostaglandine cu rol fiziologic:
* PG mentinere fct renala
* PG protectie muc gastrica

Question 31

actiune COX2

Answer 31

produsa sub actiune citokine elib in proces inflam si stari febrile

Question 32

inhibarea carei izoforme COX explica efect analgezic, antipiretic, antiinflam

Answer 32

COX2

Question 33

inhibitoare selective COX2

Answer 33

• celecoxib (celebrex)
• etoricoxib (arcoxia)
• parecoxib

Question 34

efect acid acetilsalicilic in fct de doza

Answer 34

• medii (1- 2 g pe zi) : analgezic+ antipiretic
• mari (>3g/zi): antiinflamator-rar
• mici (75-100mg/zi): antiagregant plachetar

Question 35

preparate comerciale acid acetilsalicilic

Answer 35

• Aspirina 500 mg
• cpr efervescente
• preparate tamponate- cu gluconat/ carbonat de calciu

Question 36

ce au paracetamol sinus si paracetamol plus
pe langa paracetamol

Answer 36

• antihistaminic anti H1
• vasoconstrictor pseudoefedrina

Question 37

forme farmaceutice naproxen

Answer 37

• Nalgesin 220 mg
• Naldorex 275 mg
• Nalgesin Forte 550 mg
• Vimovo= naproxen+esomeprazol 500/20mg

Question 38

cand se foloseste naproxen

Answer 38

dureri reumatice cronice

Question 39

forme de arcoxia si cand se folosesc

Answer 39

• cpr 30 mg- boala artrozica
• cpr 60 mg- boala artrozica daca 30mg nu a fost eficient
• cpr 90 mg- boli reumatice severe+ dupa interventii chir dentare
• cpr 120 mg- artrita gutoasa- maxim 8 zile

Question 40

AINS utile in/ dupa interventii stomatologice

Answer 40

• Ibuprofen
• Naproxen (Nalgesin)
• Acid mefenamic (Vidan)
• Etoricoxib (Arcoxia)
• Ketorolac

Question 41

utilizare Ibuprofen in stoma

Answer 41

400 mg de 3 ori pe zi la distanta de minim 4-6 ore

Question 42

utilizare Naproxen in stoma

Answer 42

1 cpr 220mg la 8-12 ore
maxim 3 cpr pe zi

Question 43

utilizare acid mefenamic in stoma

Answer 43

Cp 500 mg
1 cp de 3 ori pe zi

Question 44

utilizare etoricoxib in stoma

Answer 44

cpr 90 mg
1 cp/zi, maxim 3 zile

Question 45

utilizare ketorolac in stoma

Answer 45

cp 10 mg
2-4 cp/zi dupa unele interventii