local anaesthetic toxicity Flashcards
what is local anaesthetic toxicity?
Local anaesthetic toxicity is a condition that can occur when the systemic levels of local anaesthetic exceed the maximum safe dose. This leads to a blockade of sodium channels, which can disrupt normal neuronal function.
how can you work out the levels needed per pt eg lidocaine in 70kg pt?
the maximum safe dose of lidocaine is 3mg/kg. In a 70kg patient, this would be 210mg. Considering that Lidocaine 1% contains 10mg/ml, the maximum volume of lidocaine in a 70kg patient would be 21 ml.
features of local anaesthetic toxicity?
what ix do you do?
Investigations for local anaesthetic toxicity primarily involve monitoring vital signs and ECG monitoring. Blood tests may also be conducted to determine the levels of local anaesthetic in the patient’s system.
how do you manage?
The first step in managing local anaesthetic toxicity is to stop the administration of the local anaesthetic. The patient should be assessed using the ABCDE approach, and ECG monitoring should be initiated.
A lipid emulsion (20% intralipid) should be administered at a dose of 1mL/kg every 3 minutes up to a maximum dose of 3mL/kg, followed by an infusion at a rate of 0.25mL/kg/min. The maximum total dose is 8mL/kg.
