Liver Physiology

Question 1

Name the substances that can be used for conjugation in the phase 2 reaction of detoxification

Answer 1

Glucaronic acid
Sulfate
Acetyl
Glutathione

Question 2

What is used to catalyse the phase 1 reaction of detoxification

Answer 2

Cytochrome P450

Question 3

What are used to catalyse the phase 2 reaction of detoxification

Answer 3

Transferases

Question 4

What types of reactions are phase 1 reactions of detoxification

Answer 4

Functionalisation: Formation of a functional group, oxidation, reduction or hydrolysis

Question 5

What type of reaction is the phase 2 reaction of detoxification

Answer 5

Conjugation reaction

Question 6

Where in the cell are microsomal enzymes found?

Answer 6

Smooth endoplasmic reticulum

Question 7

Where in the cell are non-microsomal enzymes found?

Answer 7

Cytoplasm

Mitochondria

Question 8

Which phase of detoxification results in the greatest increase of hydrophilicity of the substance

Answer 8

Phase 2

Question 9

Which type of enzymes (microsomal or non-microsomal) are drug/diet inducible

Answer 9

Microsomal