Liver function tests Flashcards
1
Q
What causes unconjugated hyperbilirubinemia?
A
- increased production of bilirubin
- impaired or decreased hepatic uptake of bilirubin
- impaired or decreased conjugation
2
Q
What causes conjugated hyperbilirubinemia?
A
- Hepatocellular injury or disease
- Interhepatic cholestasis
- Extrahepatic cholestasis (biliary obstruction)
3
Q
What is the normal ALT to AST ratio?
A
ALT > AST
4
Q
What is the AST to ALT ratio in alcoholic liver disease?
A
2:1 or 3:1
5
Q
Is AST specific to liver tissue? When is it elevated?
A
- Non specific, found in other tissues
- Elevated in alcohol, hepatitis, and metabolic disease
6
Q
Is AST or ALT more specific to the liver?
A
ALT
7
Q
What is the half life of albumin and is it a measure of acute or chronic hepatocellular injury?
A
- 20 days
- Chronic injury
8
Q
What happens to ALT and AST with ischemia?
A
-Elevation in the thousands
9
Q
-What causes ALP to be elevated?
A
- cholestasis
- pregnancy
- bone disease/growth
10
Q
Where is GGT produced?
What causes it to be elevated?
A
- Liver, kidneys, pancreas
- Alcohol and cholestasis
11
Q
Increased ALP and low/normal GGT indicates?
A
Bone disease
