Liver And Pregnancy

Question 1

Most common cause of liver disease in pregnancy?

Answer 1

Viral hepatitis

Question 2

Why are pregnant women at an increased risk of developing gallstones?

Answer 2

1) Decreased gallbladder contractility
2) increased bile cholesterol saturation

Question 3

Laparoscopic cholecystectomy safest when?

Patients who develop Gallstone complications in the third trimester should undergo cholecystectomy when?

Answer 3

Second trimester

Postpartum

Question 4

diagnostic criteria for hyperemesis gravidarum?

Answer 4

1) Nausea/vomiting
2) weight loss of >5% of prepregnancy body weight

Question 5

1) Intrahepatic cholestasis of pregnancy
2) HELLP
3) Acute fatty liver of pregnancy

Which is associated with family history?

Liver imaging?

Answer 5

ICP

Normal
Hematoma, hepatic and function
Fatty infiltration

Question 6

1) Intrahepatic cholestasis of pregnancy
2) HELLP
3) Acute fatty liver of pregnancy

Liver histology?

Answer 6

1) Mile cholestasis without inflammation
2) Necrosis with Periportal hemorrhage
3) Pericentral microvesicular steatosis

Question 7

1) Intrahepatic cholestasis of pregnancy
2) HELLP
3) Acute fatty liver of pregnancy

Risk of maternal mortality?

Fetal risk?

Answer 7

0%; 1%; 10%

1) increased prematurity, 1% IUFD
2) increased prematurity, 10-20% perinatal mortality
3)  10-20% perinatal mortality

Question 8

Deficiency in this is related to developing acute fatty liver of pregnancy?

Answer 8

LCHAD (Long-chain 3-hydroxyacyl-CoA dehydrogenase)