Liver 1

Question 1

Role of:
1) ferroportin
2) hepcidin
3 hemojuvelin

Answer 1

1) exports iron across the basolateral membrane
2) Negative regulator of iron absorption (down regulates ferroportin)
3) protein involved in making hepcidin

Question 2

Hereditary hemochromatosis classifications;
Type I
Type II
Type III
Type IV

Answer 2

1) HFE
2) Juvenile hemachromatosis (hemojuvelin; hepcidin)
3) transferrin-2 receptor
4) Ferroportin (Gain of function and loss of function)

Question 3

when to send an HFE mutation analysis?

Went to obtain liver biopsy?

Answer 3

1) Elevated ferritin (200+ in women, 300+ in men) with no other Inflammation
2) Transferrin saturation over 45%

1) Ferritin >1000 or elevated LFTs In a patient with confirmed hemachromatosis

Question 4

Treatment for hemochromatosis:
When to do phlebotomy? How much? Until?

Answer 4

Ferritin >1000 or elevated LFTs;

One unit a week;

HCT <35% and ferritin 20-50

Question 5

Phlebotomy (in Hemochromatosis) will not fix the following once they’ve occurred

Answer 5

Cirrhosis, arthropathy, diabetes, testicular atrophy

Question 6

Anyone with hemachromatosis should avoid this supplement? Why?

Answer 6

Vitamin C; increases iron absorption