Liver Flashcards
Vessels into the liver
Hepatic artery
Hepatic portal vein (from digestive system)
Vessels out of the liver
Hepatic vein
Bike duct
Cells within the liver
Hepatocytes
Kupffer cells
Liver structure
Lobes divided into lobules (which are cylindrical)
Division of vessels within the liver
Hepatic artery and hepatic portal vein run parallel to the lobules
- Called Inter-lobular vessels
Blood is mixed in the sinusoid
Which chamber is blood mixed in
Sinusoid
Function of Kupfer cells
Breakdown and recycle old reed blood cells
Which vessel does blood drain into after the sinusoid
Branch of hepatic vein
How is bile produced
Bile is produced against the flow of blood in a different vessel (bile canaliculus)
Flows into the branch of the bile duct
Function of the liver
Storage of glycogen
Detoxification
Detoxification of alcohol
Ethanol - 2H+ -> Ethanal by reducing NAD (ethanol dehydrogenase)
Ethanal - 2H+ -> Ethanoic acid by reducing NAD (ethanal dehydrogenase)
Ethanoic acid + CoA -> Acetyl CoA
Formation of urea
Amino acid -> Ammonia + keto acid (deamination)
Ammonia -> Urea (ornithine cycle)
Deamination
Amino acid + 1/2O2 makes Keto acid + NH3
Ornithine cycle
Ornithine + NH3 + CO2 -> Citrulline + H2O
Citrulline + NH3 -> Aginine + H2O
Aginine + H2O -> Urea + Ornithine