Lipoproteins Flashcards
1
Q
describe the structure of atherosclerotic plaques
A
necrotic core, foam cells, fibrous cap
2
Q
where is cholesterol broken down and what into
A
hydroxylized in liver by CYP7AI -> bile acids which are excreted via bile ducts
3
Q
what happens to bile acids when the are excreted by the bile ducts
A
esterified by ACAT -> cholesterol esters
4
Q
what happens to the chol esters after they’ve been made
A
combined with Tg and apoB to form VLDLs
5
Q
function of PCSK9
A
binds to LDLR and promoted deg
antiPCSK9 MAb -> dec LDL
6
Q
action of statins
A
HMG-CoA reductase inhib -> dec intrinsic synth of chol in liver
7
Q
side effects of statins
A
myopathy, fatigue
8
Q
action and side effects of orlistat
A
gut lipase inhib
SEs - profound flatulence and diarrhoea
