Adrenal disease Flashcards
what are the layers of the adrenals
((((( Medulla ) Z reticularis ) Z fasciculata ) Z glomerulosa) Capsule )
what are the main causes of a wasted adrenal gland
addisons/steroids
what are the main causes of a hypoplastic adrenal gland
cushings/ectopic ACTH
how will addisons disease present
hyponat + Hyperkal + hypogly
what is the name for addisons + primary hypothy
schmidt’s syndrome
what is the test for addisons
short synACTHen test
what is the management of addisons
IV 0.9% saline + IV hydrocortisone
what do high urinary catcholamines indicate
pheochromocytoma
what is the treatment for pheochromocytoma
immediate alpha blockade
what is the risks of treating pheochromocytoma with an immediate alpha blockade
rebound tachycardia - add a beta blockade
what would you suspect if there was high plasma aldosterone and low plasma renin
Conns - primary hyperaldosteronism
what syndrome is this describing
low aldosterone, low renin, low K+, high glucose
cushings
what is the screening/investigations for cushings
check 11pm salivary cortisol - if low then not cushings
LDDST - cushings = not suppressed
what inv is used to confirm a diagnosis of cushings
inferior petrosal sinus sampling
what is the treatment for cushings
if mass - adrenalectomy
if ectopic - ketoconazole, metyrapone
