lipoprotein metabolism Flashcards
Break down products of triacylglycerols
fatty acids glycerol and monoglycride
lipoprotein metabolism overview（3 pathways）
exogenous(GI tract), endogenous(blood stream), reverse cholesterol transport
Acetyl- CoA and Acyl-CoA
Acetyl-CoA:乙酰辅酶A，乙酰基，
Acyl-CoA: 酰基辅酶A, 酰基，任意酰基
function of acetyl-CoA in lipoprotein metabolism
function of acyl-CoA in lipoprotein metabolism
when would β-oxidation occur?
low blood glucose conditions
productions of β-oxidation fatty acids
Acetyl-CoA, NADH,QH2
What enzyme can make Triacylglycerol breakdown in adipocyte
Lipase(hormone sensitive)
Triacylglycerol compoments
Fatty acids, glycerol
Fatty acid compoments
long carbon chain+ carboxyl group
what could glycerol do from triacyglycerol breakdonw?and where？
glycerol—-gluconeogenesis—->glucose
Take place in liver
where would triacylglycerol breakdown happen?
adipocyte
where would fatty acid β-oxidation happen?
liver and muscle
where would glycerol glyconeogenesis happen?
liver
how many steps for fatty acid activation in cytosol
2
Step 1 activation of fatty acid in cytosol
- Fatty acid+ATP—>acyl-adenylate+ 2Pi(phosphate)
Step 2 activation of fatty acid in cytosol
acyl-adenylate+ CoA—>Acyl-CoA + AMP
what is HSCoA
CoenzymeA CoA
where will Acyl-CoA being transported to after activation in cytosol
matrix，参与循环
β-oxidation of fatty acids in matrix
cycle: starts with Acyl-CoA, ends up with Acetyl-CoA, QH2, NADH, consumes CoA, Q, NAD+
For a saturated acyl-CoA with 2N carbons
Acyl-CoA + (N-1)Q + (N-1)NAD+, + (N-1)CoA —–>N Acetyl-CoA + (N-1) QH2 + (N-1) NADH
Electron produced for a saturated acyl-CoA oxidation with 2N carbons
14 ATP/pair of carbons in a fatty acid
what are ketone bodies
name for acetone(丙酮), acetoacetate(乙酰乙酸)， β-hydroxybutyrate（β-羟基丁酸）
where is ketogenesis take place?
Liver hepacytos
