Fundamental Concepts in Metabolism Flashcards
ΔG vs. ΔG°’
Gibbs free energy (G)
ΔG°’: “standard” free energy change
Factors affect ΔG
1) properties of the molecules
2) reaction conditions
catabolism
macromolecules—>e-, energy and building blocks
breakdown of macromolecules, produces free energy and essential building blocks
anabolism
using free energy and essential building blocks to make macromolecules
metabolism includes
catabolism and anabolism
what kind of enzyme would help Digestion (hydrolysis) of starches
amylase, breaks the glycosidic bonds between glucose units in polysaccharides like starch.
what kind of enzyme would help Digestion (hydrolysis) of proteins
protease e.g. trypsin, chymotrypsin, elastase
cleave the peptide bond between the carboxyl group of one amino acid and the amino group of another.
what kind of enzyme would help Digestion (hydrolysis) of triacylglycerols
Lipases, breaks the ester bond
what products we can get from hydrolysis of triacylglycerols?
monoacylglycerol, fatty acids, glycerol
how could fatty acids become chylomicrons?
re-esterify
ΔG = Gproducts – Greactants
G>0 not spontense
G<0 spontenase
Energetically favourable
diagram, ΔG<0, Net conversion of reactants to products
Energetically near-neutral
diagram, (Could go either way), No net reaction
follows Le Châtelier’s Principle
Energetically unfavourable reaction
diagram, ΔG>0, Net conversion of products to reactants
what charasterics do “Irreversible” reactions have
Products are strongly favoured
Insensitive to changes in concentration
