Lipoprotein functions Flashcards
1
Q
Chylomicron
A
delivers dietary TGs to peripheral tissue. After depleted of TGs, chylomicron remnants deliver cholesterol to the liver. Secreted by intestinal epithelial cells.
2
Q
VLDL
A
TGs from the liver to peripheral tissue.
3
Q
IDL
A
Formed in degredation of VLDL. TGs and chol. to liver, where degraded to LDL.
4
Q
LDL
A
cholesterol from liver to peripheral tissue. Taken up by target cells via receptor-mediated endocytosis.
5
Q
HDL
A
Cholesterol from periphery to liver. Repository for apoC and apoE. Secreted by liver and intestine.
6
Q
How does abetalipoproteinemia present?
A
Infant with failure to thrive, steatorrhea, acanthocytosis, ataxia, and night blindness. Intestinal biopsy shows accumulation w/in enterocytes b/c chylomicrons can’t be exported.
