Cramming 3

Question 1

What vitamin may be supplemented to treat measles?

Answer 1

A

Question 2

What congenital abnormalities can Vitamin A cause?

Answer 2

cleft palate, cardiac defects

Question 3

What 4 enzymes require TPP?

Answer 3

PDH, αKGdh, Transketolase, and branched chain aa dh

Question 4

Which enzyme would you test to dx thiamine deficiency?

Answer 4

transketolase

Question 5

What part of the thalamus is damaged in Wernicke-Korsakoff syndrome?

Answer 5

medial dorsal nucleus

Question 6

What is niacin (nicotinic acid) used to treat? What are the side fx of niacin tx?

Answer 6

hypercholesterolemia; facial flushing, hyperglycemia, and hyperuricemia

Question 7

How does niacin work to lower cholesterol?

Answer 7

decreases VLDL secretion, hepatic TG production, VLDL->LDL, and lipolysis in adipose tissue

Question 8

transamination (ALT, AST), decarboxylation, and glycogen phosphorylase reactions all require what cofactor?

Answer 8

B6

Question 9

How does vitamin B6 deficiency result in sideroblastic anemia?

Answer 9

required by δ-ALA synthase –> impaired Heme synth and Fe++ excess

Question 10

What drug can cause a B6 deficiency?

Answer 10

INH

Question 11

How are the manifestations of B12 and folate deficiency different?

Answer 11

No neuro Sx in folate def.

Question 12

Phenytoin, sulfonamides, and MTX can all cause a deficiency in what vitamin?

Answer 12

folate

Question 13

What is the antidote for methanol or ethylene glycol poisoning (other than ethanol)? Mech?

Answer 13

Fomepizole inhibits alcohol d.h.

Question 14

What is disulfiram?

Answer 14

inhibitor of acetaldehyde d.h. –> causes severehangover Sx from acetaldehyde accumulation