Lipids in health and disease Flashcards
what are 3 roles of cholesterol of lipids in health?
plasma membrane
cell signalling
precursor molecule
what is the function of the plasma membrane?
helps maintain structure and fluidity of cell membrane and helps provide a barrier to H+ and Na+ solutes
what is the function of cell signalling?
helps form lipid rafts that form bridges between receptor proteins and secondary messengers
why are the rafts formed from cell signalling important?
theyre part of the membrane that serves as centres for the assembly of signalling molecules
what is the function of precursor molecules?
important in digestion of fat-soluble vitamins
bile/bile acids, vitamin D and steroid hormones
what is the role of triglycerides?
contribute to the formation of the cell membrane, form lipid bilayers slong with phospholipids
triglycerides have a highly concentrated what?
energy store
how are lipids carried around the body?
by lipoproteins
what are lipoproteins?
specialised proteins that carry lipids in the aquaeous blood
lipoproteins carry lipids in the aqueous blood due to what?
the lipids hypdrophobicity
what are the two things used to work on lowering cholesterol?
evidence-based medicine and statins
what is a case-control study?
two existing groups differing in outcome are identified and compared on the basis of a casual attribute
what is a cohort study?
follows a group of people over time
what is a randomised clinical trial?
experiment in which trial participants are randomly allocated to treatment under study
what is a systematic review?
literature review focused on a research question
