Lipids

Question 1

What is a competitive inhibitior of HMG-CoA-3 hydroxy 3 methylglutaryl coenzyme A? What is important?

Answer 1

STATINS
HMG-CoA enzyme 1st in cholesterol synthesis.
1. If cell cant make cholesterol, will remove from blood
2. L/T upregulation of LDL receptors and increased breakdown of LDL, so decreases LDL and TG.

Question 2

How does statins improve atherosclerotic lesion stability?

Answer 2

decreases oxidative stress and vascular inflammation-

Question 3

Moderate Intensity Therapy 20-40 mg

Answer 3

Simvastatin/ Zocor

Question 4

High Intensity Therapy 80 mg; Moderate Intensity Therapy 10-20 mg

Answer 4

Atorvastatin/Lipitor

Question 5

High Intensity Therapy 20-40 mg; Moderate Intensity Therapy 10 mg

Answer 5

rosuvastatin

Question 6

Moderate Intensity Therapy 40-80 mg

Used often with HIV patients because less drug interactions

Answer 6

pravastatin

Question 7

CyP3A4 (lots of interactions)

Answer 7

lovastatin

Question 8

CyP2C9 (less interactions)

Answer 8

fluvastatin

Question 9

CyP2C9 (less interactions)

Answer 9

pitavastatin

Question 10

Fibric Acids

Answer 10

fenofibrate

Question 11

Fibric Acids

Answer 11

gemfibrozil

Question 12

Bile Acid Binding Resins

Answer 12

colestipol

Question 13

Bile Acid Binding Resins

Answer 13

cholesevelam

Question 14

Bile Acid Resins

Answer 14

cholestyramine

Question 15

Bile Acid Resins

Answer 15

Lomitapide

Question 16

Bile Acid Resins

Answer 16

Mipomersen

Question 17

Sterol cholesterol transport Inhibitor

Answer 17

ezetimibe

Question 18

Jah

Answer 18

Niacin/Niaspan

Question 19

CyP2C9 (less interactions)

Answer 19

evolocumab (Repatha)

Question 20

CyP2C9 (less interactions)

Answer 20

alirocumab (Praluent)